Protein Info for CCNA_01282 in Caulobacter crescentus NA1000 Δfur

Annotation: gluconolactonase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: K01053, gluconolactonase [EC: 3.1.1.17] (inferred from 100% identity to ccr:CC_1224)

Predicted SEED Role

"Gluconolactonase (EC 3.1.1.17)" in subsystem Entner-Doudoroff Pathway (EC 3.1.1.17)

MetaCyc Pathways

Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
glucose and glucose-1-phosphate degradation (3/5 steps found)
sorbitol biosynthesis II (1/3 steps found)
L-ascorbate biosynthesis IV (animals, D-glucuronate pathway) (3/6 steps found)
L-ascorbate biosynthesis VI (plants, myo-inositol pathway) (1/4 steps found)
Entner-Doudoroff pathway II (non-phosphorylative) (4/9 steps found)
glucose degradation (oxidative) (1/5 steps found)
L-ascorbate biosynthesis VIII (engineered pathway) (2/7 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.17

Use Curated BLAST to search for 3.1.1.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C656 at UniProt or InterPro

Protein Sequence (347 amino acids)

>CCNA_01282 gluconolactonase (Caulobacter crescentus NA1000 Δfur)
MTTRRAMLGAGVALIAGAQGFAAQARGAGSPKIGRIRRLSPELDAVVDANAPIEQLTDGI
TWAEGPAWVANGSYLLFSDVPGNVMHRWDAKGGKTDFLRPSGYDGPPTKIFREAGTNGAI
ISTAGELLVCDCGNRAVARIDLSTRKKTLLATTFNGKKFNSPNDLVEVRHGPLKGSLYFT
DPPYGLEGGDASPAKEQAFNGVYLLRPNGEVALVDGSLSFPNGVGLSPDGRRLYVAISDP
KRPVIMAYDLGADGLPTASRVFFDASDLLKAGGPGLPDGMKVDAQGRLFASGPGCIMILT
PDAKLLGVIETGFPAANCVFGEDGGTLFITSNHLVARVRTKTKGLGR