Protein Info for CCNA_01279 in Caulobacter crescentus NA1000 Δfur
Annotation: inorganic polyphosphate/ATP-NAD kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to NADK_CAUVC: NAD kinase (nadK) from Caulobacter vibrioides (strain ATCC 19089 / CB15)
KEGG orthology group: K00858, NAD+ kinase [EC: 2.7.1.23] (inferred from 100% identity to ccr:CC_1221)Predicted SEED Role
"NAD kinase (EC 2.7.1.23)" in subsystem NAD and NADP cofactor biosynthesis global (EC 2.7.1.23)
MetaCyc Pathways
- cytosolic NADPH production (yeast) (4/5 steps found)
- NADP biosynthesis (1/1 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
- NAD phosphorylation and transhydrogenation (1/2 steps found)
- mitochondrial NADPH production (yeast) (3/5 steps found)
- NAD phosphorylation and dephosphorylation (1/3 steps found)
- NAD(P)/NADPH interconversion (3/6 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.1.23
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0H3C7K4 at UniProt or InterPro
Protein Sequence (260 amino acids)
>CCNA_01279 inorganic polyphosphate/ATP-NAD kinase (Caulobacter crescentus NA1000 Δfur) MYQPQPFVTRLAFKCSDRPEAQEARERLAARYGDVGPENAQVIVALGGDGFMLESLHEAI ASQTPIYGMNRGSVGFLMNEYSEDGLLERINAAERAVIHPLAMVAIDARRTQHRALAINE VSLLRQTRQTAKLRISIDGKVRMGELVCDGALLATPAGSTAYNLSAHGPIIPIDGRVLAL TPISAFRPRRWRGALLPQSARVTFEILEADKRPVSAVADNFEVRDAMEVHISEDRGTSLA MLFDAGRSLEERVLAEQFSA