Protein Info for CCNA_01046 in Caulobacter crescentus NA1000 Δfur

Annotation: peptide methionine sulfoxide reductase msrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 217 TIGR00401: peptide-methionine (S)-S-oxide reductase" amino acids 46 to 200 (155 residues), 224.3 bits, see alignment E=4.3e-71 PF01625: PMSR" amino acids 47 to 200 (154 residues), 213.9 bits, see alignment E=6.8e-68

Best Hits

Swiss-Prot: 100% identical to MSRA1_CAUVC: Peptide methionine sulfoxide reductase MsrA 1 (msrA1) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K07304, peptide-methionine (S)-S-oxide reductase [EC: 1.8.4.11] (inferred from 100% identity to ccs:CCNA_01046)

MetaCyc: 60% identical to methionine sulfoxide reductase A (Escherichia coli K-12 substr. MG1655)
L-methionine (S)-S-oxide reductase. [EC: 1.8.4.13]; Peptide-methionine (S)-S-oxide reductase. [EC: 1.8.4.13, 1.8.4.11]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)" (EC 1.8.4.11)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.4.11

Use Curated BLAST to search for 1.8.4.11 or 1.8.4.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6C7 at UniProt or InterPro

Protein Sequence (217 amino acids)

>CCNA_01046 peptide methionine sulfoxide reductase msrA (Caulobacter crescentus NA1000 Δfur)
MLSLHKTLEMPSADTALPGRAAPIPTAQTHFVNGHALKGPYPEGLETAIVAMGCFWGVER
VFWKVPGVYVTAAGYAAGITPNPTYEEVCTGRTGHTEVVLVVFDPKVVTYEALLKTFWEN
HDPTQGMRQGNDIGTQYRSGLYVTSDAQAAAAAESKAAYQQALSARGLGTITTEIAPAGP
FYFAEDYHQQYLAKNPNGYCGIGGTGVVCPIGLGVEG