Protein Info for CCNA_01015 in Caulobacter crescentus NA1000 Δfur

Annotation: multicopper oxidase PcoA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 561 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 2 to 554 (553 residues), 964.9 bits, see alignment E=7.7e-295 PF07732: Cu-oxidase_3" amino acids 49 to 159 (111 residues), 135.7 bits, see alignment E=1.3e-43 amino acids 443 to 555 (113 residues), 24 bits, see alignment E=5.3e-09 PF00394: Cu-oxidase" amino acids 232 to 333 (102 residues), 73.1 bits, see alignment E=4.2e-24 PF07731: Cu-oxidase_2" amino acids 439 to 555 (117 residues), 108.4 bits, see alignment E=3.8e-35

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccr:CC_0964)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C598 at UniProt or InterPro

Protein Sequence (561 amino acids)

>CCNA_01015 multicopper oxidase PcoA (Caulobacter crescentus NA1000 Δfur)
MMTAFDRRTLLQGALSLGAAGLLPGWATAAGGERSPPALSGEEIKLTVGHTMAKIDGKAG
HAVTVNGAIPGPLIRLKEGQNVRLSVTNTLDEDTSIHWHGLLVPFQMDGVPGVSFPGIKP
GETFTYEFPIRQSGTYWWHSHSGLQEQMGHYGPMIIDPAGEDPVAYDREHVVVLSDWSFL
HPHELFRKLKVSAGHFNRQKQTVAGLLKGQDQSLKDRVAWGQMRMDPTDIADVTGSVYTY
LMNGHGPGDNWTGLFAPGERVRLRFINAGAMTIFNVRIPGLSLEVVGTDGQLVSPVAVDE
FQIAPAETFDVIVRPTEDKAFTLVAEASDRSGMARGTLAPRLGMTAAVPPLRRRPLANMK
DMGMGNMHHGMDMPGMDMSMRAQSNAPNVPLTPGVQTISPMPMDRMVEPPQGLEDAGHRV
LTYADLASLYPPKDSRAPGRTIEIHLTGNMERFMWAFDGEAFGPLKKPIAFQRDERARVV
LINDTMMAHPIHLHGHFFELVNGQERQPLKHTVNVAPGGKVAFDLTADEPGDWAFHCHML
LHMHAGMFNVVTVRPLDGAAA