Protein Info for CCNA_00630 in Caulobacter crescentus NA1000 Δfur

Annotation: chemotaxis histidine kinase protein cheAII

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 764 PF01627: Hpt" amino acids 3 to 95 (93 residues), 57.9 bits, see alignment E=2e-19 PF02895: H-kinase_dim" amino acids 213 to 272 (60 residues), 52 bits, see alignment 1.6e-17 PF02518: HATPase_c" amino acids 320 to 459 (140 residues), 54.9 bits, see alignment E=2.2e-18 PF01584: CheW" amino acids 465 to 592 (128 residues), 89.3 bits, see alignment E=3.6e-29

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 100% identity to ccr:CC_0594)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C5W6 at UniProt or InterPro

Protein Sequence (764 amino acids)

>CCNA_00630 chemotaxis histidine kinase protein cheAII (Caulobacter crescentus NA1000 Δfur)
MDDLIADFLVEAHEGLEVIDVELVRFEARPEDRAALDKIFRLVHTLKGACGFLGLGRLEA
IAHAGETLLGRFRDGRLEVSSQAVTAVLSAIDRIKMILDGLGDLGREPEGDDTALIQALE
AFSDGAAPSEQSPVAAEPEPLAADVAAPERTLRPGEVSLEELEAAFLAAEGPVFDAPAPP
VETPSAASPAATFEPDQTDSAPEALVSESLGPQTIRVGVDVLEDMMTLVSELVLTRNQLL
QLNRGRGDETFTPPLQRLSSITGELQDSVMKTRMQPIGQAWKKLPRLVRDLSGELGKPIE
LVMEGEATELDRQVLEQIRDPLTHMVRNSADHGLEGPEARRAAGKPEAGLIHLSAYHEGG
AIVIRLRDDGRGLDTARIREKAIEKGIVGRAEAETMTEAQVHRLIFAPGFSTAAVVTNVS
GRGVGMDVVRSNIEQIGGQIELQSTLGQGCVVTVKIPLTLAIVSALIIRAAGERFAVPQA
SVQELVKVSADSDHRFEEIEHVRMLRLREQLIPLIDLSEELGRERRHEAKFVLIMRVGAH
RFGVLVEEVIDTEEIVVKPLASVLRTIPVFSGATLLGDGSVVLIIDPNGLSDRAGDMPAR
AQKAIDEAAVWTEAEAAELVSLLIVRVGAGALKAVELSRITRLEQVPVATIQSIGDRAAV
DYRGKLMPVLTIEEGQRFVESGSQPLLVVQGMLYAMGLAVDQIVDVVGAKLDIELTASRP
GVRGVALVNGRATELLDLDHFMLLALAEHAKGATGGDADGRIAA