Protein Info for CCNA_00385 in Caulobacter crescentus NA1000 Δfur

Annotation: multidrug resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 444 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 41 to 63 (23 residues), see Phobius details amino acids 74 to 96 (23 residues), see Phobius details amino acids 108 to 136 (29 residues), see Phobius details amino acids 149 to 169 (21 residues), see Phobius details amino acids 175 to 195 (21 residues), see Phobius details amino acids 223 to 250 (28 residues), see Phobius details amino acids 263 to 283 (21 residues), see Phobius details amino acids 295 to 327 (33 residues), see Phobius details amino acids 370 to 393 (24 residues), see Phobius details amino acids 404 to 424 (21 residues), see Phobius details PF07690: MFS_1" amino acids 14 to 366 (353 residues), 99.2 bits, see alignment E=1.2e-32

Best Hits

KEGG orthology group: K08217, MFS transporter, DHA3 family, macrolide efflux protein (inferred from 100% identity to ccs:CCNA_00385)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C4F6 at UniProt or InterPro

Protein Sequence (444 amino acids)

>CCNA_00385 multidrug resistance protein (Caulobacter crescentus NA1000 Δfur)
METRFVTPFHHLLVNNLVANITNFTIWFALTFYVYLETKSVFATGMIAGVYLVLTAACGI
WFGSLVDHHRKKLAMAGSSLASLLLYALALAVLLLAPKGAIADVGRPWLWALIGLSMLGV
IAGNIRTIALPTLVTLLIPEDRRDKANGLVGMVSGVGFLTTSVISGFLVAWGGMLAALTF
ALGFTVAALVHLLTVPVDEPRVEAEHGAPVAPRRIDLAGTIKVVAAVPGLFALILFATFN
NFLGGIFMALLDAYGLSMVSVQAWGLLFGFLSVAFIISGLAISKTGLGKNPLRTLLLVNL
ISWAVCCVFPLKSSIVMLAMGCFVWMLLGPYAEAAEQTTLQKVVPFERQGRVFGFAQSVE
QAASPLTAFLIGPLTQFIVIPFMTHGAGAAAIGDWFGRGPDRGMALVFTLAGVVGLIVTL
LAFGSKAYRQLSAAYAQGEPAPAA