Protein Info for CCNA_00252 in Caulobacter crescentus NA1000 Δfur

Annotation: multimodular transpeptidase-transglycosylase PbpX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 653 transmembrane" amino acids 21 to 45 (25 residues), see Phobius details PF00912: Transgly" amino acids 78 to 244 (167 residues), 206 bits, see alignment E=3.2e-65 TIGR02074: penicillin-binding protein, 1A family" amino acids 83 to 599 (517 residues), 643.6 bits, see alignment E=1.4e-197 PF00905: Transpeptidase" amino acids 332 to 561 (230 residues), 116.5 bits, see alignment E=1.5e-37

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccr:CC_0252)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6C5 at UniProt or InterPro

Protein Sequence (653 amino acids)

>CCNA_00252 multimodular transpeptidase-transglycosylase PbpX (Caulobacter crescentus NA1000 Δfur)
MANGPFGGNPPAKPQRTPLQALIYWGSVVGVWGLIFVVAFFAVFASDLPDTSKLYDVKRQ
PSINYLDRSGALLAVRGSQYAPPVDLDALPKYVPAAFIAIEDRQFYHHFGFNPWGIIRSA
AWNLTHDGPQRGGSTITQQLARNLFLSPAQNYRRKAQELILAIWLELKFSKKQILALYMN
RVYFGAGAYGIEAASQRYFNKPANQLTIGEAALLAGMMKGPARYSPVSAKERAARRATIV
LDEMVRIKAITAEERDEAFRTPVQVSATLANQRAQYFTDYIDAQVRSLVGEPTEDLVVET
TMDLPIQVAAERAVKLGVEGHIKQGVQQAALVAIDGEGRIRAYVGGADYNDSQFDRATTA
RRQAGSAFKPFVFLTAMEAGRTPNVMVVDEPVKIGNWEPKNYTNKYLGPITLQTALAQSI
NTVAARLANEVGTSNVAATARRLGITSKIQLDPSMALGAVEVSPMEMAQAYAPFANGGFL
AKGYGIERIRTASGKVLYDHSVDKQARAAVIGSPSLQYMNQMMREVVATGTGTRARVASY
DIAGKTGTTSDYKDAWFVGYTGGFVTAVWTGKDDATPMKRVTGGGAPAEVWRVFMAAALP
RLKATPIPGGFIEPPPVAPIDPIGDLVDAPPAPEGPAAEAPAGEPPPADQLPY