Protein Info for CCNA_00214 in Caulobacter crescentus NA1000 Δfur

Annotation: TonB-dependent receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 681 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF07715: Plug" amino acids 54 to 157 (104 residues), 71.9 bits, see alignment E=5.8e-24 PF00593: TonB_dep_Rec_b-barrel" amino acids 305 to 650 (346 residues), 130.4 bits, see alignment E=1.8e-41

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 100% identity to ccs:CCNA_00214)

Predicted SEED Role

"Zinc-regulated outer membrane receptor" in subsystem Transport of Zinc

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C421 at UniProt or InterPro

Protein Sequence (681 amino acids)

>CCNA_00214 TonB-dependent receptor (Caulobacter crescentus NA1000 Δfur)
MIRRVALSAASLLVLAAATAAHAKDAAAPPASAQDAEVSKVIVTAAPYGVSADALTASVA
VLDRTDLDLAAPKGLGDALAGLPGVRSTTFGAGASRPVVRGLAGPRVQVLTNGVGQIDAS
ALSPDHQVATDPGEAERIEVLRGPAALAYGGSAIGGVVNIIDDRISTQQPIDGMSGRLLA
SRGTGDDSYALSGAVHATVGPMVLTLDALKRESKDYKIPVYPESARQLALEGETAEGGAG
RLENSAVDLETFGAGLSYVGDKGFVGMSIKRTDSTYGVPGHAHEHEGEAEAGHEEESAVT
IGLKQTRIDLRGEYDADLGPFAKVRFSGGHADYTHTEFEGDAVGTKFTSDGYEGRLELVQ
TERGGWKGAVGVQALRRNFDAIGDEAYVPKTKITEFGAFTQQRLELDGYGYEGGLRIDTR
ELDSLKGKADFTNLSGSVGAFWRPTTESFVGLALSRSSRAPTESELFAEGPHAATRGFEI
GDADLKEETATSLEATLHYGGERVSGDLHLYIARYDGFIDLRPTGDEEDGLAVYRYVQTD
AEFRGFEAELAYRVWTDGQRSVNLHAGADFVRGSSDLGPPARIPPYSVSLKASYQAPMWS
GDVEVRRTGGQERVAQMELPTDGYTVLNATLAWKPAGNARVRLFLDGRNLTNEEVREHVS
FLKDIAPSPGRQVRAGIALRF