Protein Info for CCNA_00144 in Caulobacter crescentus NA1000 Δfur

Annotation: oxygen-independent coproporphyrinogen-III oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 384 TIGR00539: putative oxygen-independent coproporphyrinogen III oxidase" amino acids 11 to 336 (326 residues), 259.2 bits, see alignment E=3.1e-81 PF04055: Radical_SAM" amino acids 12 to 178 (167 residues), 77.2 bits, see alignment E=1.7e-25 PF06969: HemN_C" amino acids 312 to 374 (63 residues), 41.7 bits, see alignment E=1e-14

Best Hits

KEGG orthology group: K02495, oxygen-independent coproporphyrinogen III oxidase [EC: 1.3.99.22] (inferred from 100% identity to ccs:CCNA_00144)

Predicted SEED Role

"Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB" in subsystem Heat shock dnaK gene cluster extended or Heme and Siroheme Biosynthesis or Queuosine-Archaeosine Biosynthesis

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.22

Use Curated BLAST to search for 1.3.99.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C631 at UniProt or InterPro

Protein Sequence (384 amino acids)

>CCNA_00144 oxygen-independent coproporphyrinogen-III oxidase (Caulobacter crescentus NA1000 Δfur)
MTDPRAEAVGIYVHWPYCARICPYCDFNVVRDRGRTDEQRALADAIVADLEAQRALTGER
RLLSIFFGGGTPSLMDPAQVARVIETAKRLWSPADDLEISLEANPTDAETDRFAALAAAG
VQRLSLGVQALDDASLKALGRNHDAGAARRAIAAAARAFPRLSIDLIYARPGQTDAAWRA
ELSEAIALGPEHVSPYQLTIEPGTAFDRAVGRGTLVTPDEDLAATLFETTQEIFEAAGFD
AYEVSNHARGEAARARHNLVYWRGVDYVGVGPGAHGRLALPEGRAATTAHRAIKDYIAAV
GDHGVGFQSEILTPEDAALERLVLGMRIDAGVGFDEVAVLGLDPDVAKVRDLVETGLLVE
DRARLRATRAGRLVLDRLTGALAT