Protein Info for CA264_21425 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: copper-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 755 transmembrane" amino acids 111 to 129 (19 residues), see Phobius details amino acids 135 to 158 (24 residues), see Phobius details amino acids 170 to 189 (20 residues), see Phobius details amino acids 201 to 220 (20 residues), see Phobius details amino acids 354 to 375 (22 residues), see Phobius details amino acids 385 to 406 (22 residues), see Phobius details amino acids 701 to 723 (23 residues), see Phobius details amino acids 729 to 748 (20 residues), see Phobius details PF00403: HMA" amino acids 25 to 84 (60 residues), 54 bits, see alignment 3.6e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 150 to 751 (602 residues), 619.3 bits, see alignment E=1.4e-189 TIGR01525: heavy metal translocating P-type ATPase" amino acids 168 to 750 (583 residues), 649.8 bits, see alignment E=9.3e-199 TIGR01494: HAD ATPase, P-type, family IC" amino acids 210 to 718 (509 residues), 301.1 bits, see alignment E=2.4e-93 PF00122: E1-E2_ATPase" amino acids 238 to 418 (181 residues), 201.2 bits, see alignment E=2.1e-63 PF00702: Hydrolase" amino acids 436 to 655 (220 residues), 112.2 bits, see alignment E=8.9e-36 PF08282: Hydrolase_3" amino acids 628 to 679 (52 residues), 22.9 bits, see alignment 1.3e-08

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 69% identity to shg:Sph21_0281)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YYR4 at UniProt or InterPro

Protein Sequence (755 amino acids)

>CA264_21425 copper-translocating P-type ATPase (Pontibacter actiniarum KMM 6156, DSM 19842)
MENKVLTPDKAVGQPTAQEQRVSLPVTGMSCASCALSVESMVGAQPGVSQAAVNFASQTL
QVSYNPDKITLAEIQRNVQEIGFDLIVDEENAQEKQEEEQHNRYQTLKKRTIAAAILTLP
VFIIGMFFMDMPYGNWIMMVLSAPVLFYFGRSFFINAFKQARNGKANMDTLVSLSTGIAF
GFSVFNTFFPEFWHTRGLHPHVYFEAAAVVIVFIMLGKLLEERAKSNTSTAIKKLIGLQP
KTVWLVEGEHEREVPISQVQKGDLLLVRAGEKIPVDGEVAQGTSYVDESMISGEPVPVAK
QKGDKVYAGTINQKGSFRFVAEKVGSETMLAQIIKMVQEAQGSKAPVQKLVDKIAGIFVP
VVLLIALVSFTTWLMLGGDNALTQGLLALVTVLVIACPCALGLATPTAIMVGVGKGAENG
ILIKDAESLEQAHKVNAVILDKTGTITEGKPVLTDIIWAGGAEARKQTLQTILLSLELQS
EHPLAEAVVRYLKDQEVRSLELDTFDSVTGRGVKASLHGNRYLAGNHRLLEEEGVHVDAK
LTQLASSLRDEAKTVIFFTENSSAVALVAIADQIKQSSAAAIRTLQEQDIEVYMLTGDNQ
QTAASVAAQVGIRNYKAEVLPSDKAAFVKDLQTQGKVVAMVGDGINDSHALAQADVSVAM
GKGSDIAIDVAKMTLISSDLQQVPKALKLSKQTVRAIKQNLFWAFIYNLIGIPIAAGVLY
PLYGFLLDPMIAGAAMALSSVSVVTNSLRLKAQKL