Protein Info for CA264_21095 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 839 transmembrane" amino acids 203 to 222 (20 residues), see Phobius details amino acids 228 to 246 (19 residues), see Phobius details amino acids 258 to 275 (18 residues), see Phobius details amino acids 281 to 298 (18 residues), see Phobius details amino acids 446 to 465 (20 residues), see Phobius details amino acids 477 to 500 (24 residues), see Phobius details amino acids 791 to 810 (20 residues), see Phobius details amino acids 816 to 835 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 260 to 833 (574 residues), 594.6 bits, see alignment E=3.7e-182 PF00122: E1-E2_ATPase" amino acids 310 to 505 (196 residues), 182.7 bits, see alignment E=5.1e-58 TIGR01494: HAD ATPase, P-type, family IC" amino acids 392 to 810 (419 residues), 210.8 bits, see alignment E=4.1e-66 PF00702: Hydrolase" amino acids 524 to 742 (219 residues), 128 bits, see alignment E=5.9e-41

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 70% identity to shg:Sph21_0227)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YYV0 at UniProt or InterPro

Protein Sequence (839 amino acids)

>CA264_21095 heavy metal translocating P-type ATPase (Pontibacter actiniarum KMM 6156, DSM 19842)
MEKLKIEIPLILPEVPDEKDRCVRELMGRLQGREGIESVHVSTGQEDGVPQLCFHYNPDE
ISMARIEALARQTGASLTEKVGHGLIAIDGIRHARHARHLEQTLLQADGVLQASVAASGM
VRLEYDRSRTNKEKILSVIREEGLRITDTSLSAADYASRTGERQDGAVAEEMERLEEKLE
PDNEHGHEHTHGHGGILGKNTELIFSITCGALLGTGFGLSFVEGVPGGVSLALYIGAYFF
GGFFTAKEAVEEILKKNFEIDFLMLVAAIGAAILGEWAEGALLLFLFSLGHALEHYAMNK
ARKSIAALAELAPKTALLKKNGKTEEVGIETLRLGDVIMVRPNSKISADGVVVKGQSSVN
QAPITGESVPVDKEPVGDPEQTYNAESEIKDENRVFAGTINGNSTLEVKVIKEARDSTLS
RLVKLVNEAQTQKSPTQRFTDKFERYFVPSVLILVVLLHFAFLVIDEPFSASFYRAMAVL
VAASPCALAISTPSAVLSGVARAARGGVLIKGGRPLEDLGVLTALAFDKTGTLTEGKPKL
TNVIPWNNEPEDGLLKKAVAVEALSDHPLAKAIVRDGKERLKDIPVPDAEHLEAVLGKGI
KASLAGNKVYIGNLELFEELDATKPSQKLVGKVQLLEAEGNTTMLVRENDRYIGIISLMD
TPRAAARATLEELKKIGIRRMIMLTGDNQKVADAVAKQIGLTDAWGSLLPEEKVEAIKEL
RQQESKVAMVGDGVNDAPAMANSTVGIAMGAAGSDVALETADIALMSDKLENLPFAIGLS
RKSKSIIKQNLWVSLGIVAVLIPSTILGLANIGVAVLIHEGSTLLVVFNALRLLAYKKK