Protein Info for CA264_21080 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 675 transmembrane" amino acids 63 to 81 (19 residues), see Phobius details amino acids 93 to 112 (20 residues), see Phobius details amino acids 119 to 137 (19 residues), see Phobius details amino acids 143 to 161 (19 residues), see Phobius details amino acids 292 to 312 (21 residues), see Phobius details amino acids 324 to 346 (23 residues), see Phobius details amino acids 623 to 645 (23 residues), see Phobius details amino acids 651 to 668 (18 residues), see Phobius details TIGR01512: cadmium-translocating P-type ATPase" amino acids 124 to 670 (547 residues), 499.9 bits, see alignment E=1.2e-153 TIGR01525: heavy metal translocating P-type ATPase" amino acids 125 to 668 (544 residues), 545.6 bits, see alignment E=2.4e-167 TIGR01494: HAD ATPase, P-type, family IC" amino acids 144 to 646 (503 residues), 254.1 bits, see alignment E=3.2e-79 PF00122: E1-E2_ATPase" amino acids 174 to 354 (181 residues), 163.9 bits, see alignment E=2.9e-52 PF00702: Hydrolase" amino acids 370 to 576 (207 residues), 101.2 bits, see alignment E=9.9e-33

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 63% identity to fte:Fluta_0455)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YYM1 at UniProt or InterPro

Protein Sequence (675 amino acids)

>CA264_21080 heavy metal translocating P-type ATPase (Pontibacter actiniarum KMM 6156, DSM 19842)
MKKERNKSKNIEEDFKPLEITSPRTAEASGPNVGTECCSADGKAKFAGADEHDHAEEEAK
SSYVPTAISLVLLLGGILLDYLDTPWFTGSVRFLSYAIAYVLVGWRVVWHAIKSLRSSFF
NEFFLMSMATLGAFYIGEYAEGVAVMLFYVIGEHFQEAAVLRSRRSIKALIDNRPDEVGL
VTDNGIVTVKAKEVQVGEVVQVKAGERVALDGELLSERSSFNTAALTGESKPDTKKKGET
VLAGMINLDRVIELRVTSAYENSALSKILKLVEEAGSRKAKTQQFITRFAKVYTPIVFFL
AVGLVFIPYFFVEAYDFNQWLYRALIFLVISCPCALVISIPLGYFGGIGAASRNGLLFKG
SNFLDLMTQVDTVVMDKTGTLTEGVFQVRQVETFLDDKGWFLSAVAALESKSTHPIAQAI
VAEAGDTYRQHTVGQVEEISGHGLKGKVDGKELLVGNTRLLERFGVLYDPSLKEIVETIV
VVAVGGTYAGYITIADKVKEDAPLAVSRMRELGVKKLVMLSGDKDSIVQKVAGELKLDEA
HGGLLPQDKVSQVEKLKAEGRTVAFVGDGINDAPVITLADVGMAMGGLGSDAAIETADVV
IQTDHPSKIATAINIGKKTKQIVWQNISLAFGVKAIVLILGAGGLATMWEAVFADVGVAF
LAILNAVRIQRMKFK