Protein Info for CA264_20940 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: pyridine nucleotide-disulfide oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 444 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF07992: Pyr_redox_2" amino acids 3 to 315 (313 residues), 185.4 bits, see alignment E=8.5e-58 PF01134: GIDA" amino acids 4 to 62 (59 residues), 22.8 bits, see alignment E=2.3e-08 PF13738: Pyr_redox_3" amino acids 120 to 297 (178 residues), 41.1 bits, see alignment E=6.9e-14 PF00070: Pyr_redox" amino acids 165 to 242 (78 residues), 58.3 bits, see alignment E=4.5e-19 PF02852: Pyr_redox_dim" amino acids 335 to 439 (105 residues), 86.6 bits, see alignment E=6.6e-28

Best Hits

KEGG orthology group: K00383, glutathione reductase (NADPH) [EC: 1.8.1.7] (inferred from 54% identity to mtt:Ftrac_2118)

Predicted SEED Role

"similar to glutathione reductase"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YZ13 at UniProt or InterPro

Protein Sequence (444 amino acids)

>CA264_20940 pyridine nucleotide-disulfide oxidoreductase (Pontibacter actiniarum KMM 6156, DSM 19842)
MKYDVFVIGAGMAGAAVAKKCAKAGLKTAISDFRPYGGTCALRGCDPKKVLIDGASLQEQ
VQRHLGKGLNGEVKIDWGELMTFKDTFTDPVPENMEKGFEKAGIDTYHAPVSFLNESTLQ
VGQEEIFAERIVVVTGARPRVLDAQGVAYTITSDDFLNLEALPEHITFLGGGYISFEFAH
LAARAGTRVTIIEHGPRPLKHFEQDMVDELMRVSEEAGIDIILNCQVQCITQKGSGYEVS
LEGRETLETGLVVSAIGRVPEVGQLELNKGKVRHGRKGIAVNEYLQSTSNPRVYAAGDVA
DTEGLPLTPVAVYEGHFLATNIIKGNSKKVNYPEIPTVVFTIPSLASVGLTEKQAREQGL
DYKVKTHDARQWFNGRRHRAHAYAYKVLMSKTDGSILGAHLVGPFAEETINIFALAMKAG
MKARDLKSFPFSYPSMASDVSYMS