Protein Info for CA264_20555 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: 6-pyruvoyl tetrahydrobiopterin synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01242: PTPS
  • amino acids 5 to 134 (130 residues), 117.4 bits, E=1.9e-38

Best Hits

Swiss-Prot: 40% identical to PTPS_HUMAN: 6-pyruvoyl tetrahydrobiopterin synthase (PTS) from Homo sapiens

KEGG orthology group: K01737, 6-pyruvoyl tetrahydrobiopterin synthase [EC: 4.2.3.12] (inferred from 74% identity to mtt:Ftrac_0669)

MetaCyc: 40% identical to 6-pyruvoyl tetrahydrobiopterin synthase monomer (Homo sapiens)

Predicted SEED Role

"6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)" in subsystem Folate Biosynthesis or Pterin biosynthesis (EC 4.2.3.12)

MetaCyc Pathways

• drosopterin and aurodrosopterin biosynthesis (5/7 steps found)
• erythro-tetrahydrobiopterin biosynthesis I (2/4 steps found)
• threo-tetrahydrobiopterin biosynthesis (2/4 steps found)

KEGG Metabolic Maps

• Folate biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.3.12

Use Curated BLAST to search for 4.2.3.12

Sequence Analysis Tools

See A0A1X9YXF8 at UniProt or InterPro

Protein Sequence (135 amino acids)

>CA264_20555 6-pyruvoyl tetrahydrobiopterin synthase (Pontibacter actiniarum KMM 6156, DSM 19842)
MKVTVCRKEHFNAAHRLHNPAWTDEQNNAVFGLCNNPNYHGHNYELIVKLTGTVNPDTGY
VYDMKKLSDLVKEQVVNKFDHKNLNLDTEEFSNLNPTAENIAVVIWNKLREQISSDYELA
ITLYETERNFVEYNG