Protein Info for CA264_20470 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 43% identical to PYRR_GEOSW: Bifunctional protein PyrR (pyrR) from Geobacillus sp. (strain WCH70)

KEGG orthology group: K02825, pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC: 2.4.2.9] (inferred from 66% identity to mtt:Ftrac_0799)

Predicted SEED Role

"Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR" in subsystem De Novo Pyrimidine Synthesis or LMPTP YwlE cluster (EC 2.4.2.9)

MetaCyc Pathways

superpathway of pyrimidine ribonucleosides salvage (9/10 steps found)
superpathway of pyrimidine nucleobases salvage (4/4 steps found)
pyrimidine nucleobases salvage II (2/2 steps found)
pyrimidine nucleobases salvage I (1/1 steps found)

KEGG Metabolic Maps

Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.9

Use Curated BLAST to search for 2.4.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YXD0 at UniProt or InterPro

Protein Sequence (182 amino acids)

>CA264_20470 bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase (Pontibacter actiniarum KMM 6156, DSM 19842)
MQKRLIVNQQLLEIMVMRLCHQLIENHGDFSDSVILGLQPRGKYVAQRIQSTLSSILGKQ
VPTGLLDTTFYRDDFRRRDTPLAANATKIDFLVEGKKVILVDDVLYTGRSVRAALDAMIA
FGRPANVELLVLVDRLYTRHLPIQPTYVGHQVNSLQSQRVLVEWKEQQANEDAIWLVTKS
DE