Protein Info for CA264_20365 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1207 PF02811: PHP" amino acids 6 to 179 (174 residues), 179.3 bits, see alignment E=2e-56 TIGR00594: DNA polymerase III, alpha subunit" amino acids 288 to 1081 (794 residues), 996.4 bits, see alignment E=8.7e-304 PF07733: DNA_pol3_alpha" amino acids 355 to 612 (258 residues), 332.9 bits, see alignment E=3.8e-103 PF17657: DNA_pol3_finger" amino acids 615 to 776 (162 residues), 230.4 bits, see alignment E=1.9e-72 PF14579: HHH_6" amino acids 852 to 942 (91 residues), 96.2 bits, see alignment 2.8e-31 PF01336: tRNA_anti-codon" amino acids 1044 to 1124 (81 residues), 39.5 bits, see alignment 1.1e-13

Best Hits

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YXB0 at UniProt or InterPro

Protein Sequence (1207 amino acids)

>CA264_20365 DNA polymerase III subunit alpha (Pontibacter actiniarum KMM 6156, DSM 19842)
MPVFSHLHTHTQYSLLDGQASISALMKKAQADGMPAVAMTDHGNMFAAFNFVAEANKYNV
KPIVGCEFYLVKDRHLKTFSKEVKDVRHHQLLLAKDQEGYQNLAKLCSLSYIEGVYSKWP
RIDKELLLKYSKGLIATSCCIGAEVPQAILWKSEEEAEEIFKWWLDVFGEDYYIEIQRHG
LQNIDGTGKSQEDINQVLLKWAKKYNVKVICTNDSHYVDQEDWNAHDILLCVNTGEDQST
PVGDFQTKYYRFLSDDQKVIYDTVENVRSKYSNHSTVRQMLNRIDEAGPKTRFGFPNDQF
YFKTQAEMNELFKDVPEAVDNTNEIVDKITPPKLKRDILLPNFPIPPEHAGPDAFLRHLT
YEGAKKRYTDITPDVEERLDYELRIIETMGFAGYFLIVQDFINRGRDMGVFVGPGRGSAA
GSAVAYCIGITNIDPIKYNLLFERFLNPERVSMPDIDIDFDDVNRQRVIDYVVDKYGKTQ
VAQIITFGTMAAKSSIKDVARSTSLPLAEANELAKMVPDTPGTTLAKAFMENLDLAAIRE
GTDHRAAVLKLAEKLEGSVRNTGIHAAGVIIAPDDITNYIPVSTSKDADLLVTQFDGKVI
ESAGMLKMDFLGLKTLTIIKDALELIKKNHGVEIDIDEIPIDDEKTYQLYQRGDTIGTFQ
FESEGMRMYLKDLQPTNIEDLIAMNALYRPGPMQFIPNFINRKHGREDVEYPHELLEPIL
NYSYGIMVYQEQIMQTAQILAGYSLGGADLLRRAMGKKDMKKMAEEREKFIAGAAEIHKI
PSKKASEVFDVMEKFAQYGFNRSHSAAYSVVAYQTGYLKAHYPAEYMAAVLTNNMNDIKK
VTFFIEEARKQGVAVLGPDVNESLLKFNVNEQGQIRFGLAAIKGTGESAVDAIISEREAN
GMYQDIFDFSKRVNLRAVNKKTFESMALAGCFDSWELYHRAQLMEVPEGESMSLLEKAVR
YGNNYQAEQQAAQQSLFGGSAAVAAPMPKIPEVQPWTQAEMLRREKEVVGFYMSGHPLDQ
FKLEIDSYCTCALSNIEEYKNRDVNVAGMVTDVVIRTAKNGNPFALFTIEDYDTTMQMAL
FGEDYVKFSPYLKIGLYLFIRGKVQLRYKTEDQWELKPQNIQLLGDVMDKMAQGVQLNIN
LQHFTPNLAEALEGAIVASVGQKRLEITLHVPEEKLALPTYSRKYRIDPKLFITSIKDMG
LGECKLI