Protein Info for CA264_19790 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 19 to 131 (113 residues), 141.2 bits, E=3.4e-45
• PF02770: Acyl-CoA_dh_M
  • amino acids 135 to 226 (92 residues), 74.5 bits, E=1.2e-24
• PF00441: Acyl-CoA_dh_1
  • amino acids 239 to 383 (145 residues), 117.7 bits, E=1.1e-37
• PF08028: Acyl-CoA_dh_2
  • amino acids 253 to 372 (120 residues), 42.4 bits, E=1.7e-14

Best Hits

Swiss-Prot: 52% identical to GCDH_PIG: Glutaryl-CoA dehydrogenase, mitochondrial (Fragment) (GCDH) from Sus scrofa

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 82% identity to mtt:Ftrac_1182)

MetaCyc: 57% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (10/15 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Sequence Analysis Tools

See A0A1X9YX20 at UniProt or InterPro

Protein Sequence (392 amino acids)

>CA264_19790 acyl-CoA dehydrogenase (Pontibacter actiniarum KMM 6156, DSM 19842)
MAYESSGAPDYYNIDDLLTEEHLLIRQTMRDFVKREISPNIEQWAQDAHFPSEIVKKFGD
VGAFGPTIPTEYGGGGLDYISYGIIMQEIERGDSGMRSTASVQGSLVMYPIYKYGSEEQR
KKYLPKLASGEWLGCFGLTEPDHGSNPGGMVTNIKDMGDHYLLNGAKMWISNSPECQVAV
VWAKNEEGRIKGLIVERGMEGFSTPEIHNKWSLRASCTGELVFDNVKVPKENLLPNVEGL
RGPLGCLDSARYGISWGAIGAAIDCYESARKYSMERIQFDKPIGAFQLTQKKLAEMLTEI
TKAQLLAWRLGSLMNEGKATTQQISMAKRNNVDMALHIAREARQIHGGMGITGEYPIMRH
MMNLESVITYEGTHDIHLLITGADITGISAFK