Protein Info for CA264_19025 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: methionine adenosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00438: S-AdoMet_synt_N
  • amino acids 3 to 99 (97 residues), 150.2 bits, E=3.2e-48
• TIGR01034: methionine adenosyltransferase
  • amino acids 4 to 395 (392 residues), 492.9 bits, E=2.9e-152
• PF02772: S-AdoMet_synt_M
  • amino acids 113 to 254 (142 residues), 137.1 bits, E=4.9e-44
• PF02773: S-AdoMet_synt_C
  • amino acids 256 to 395 (140 residues), 190.9 bits, E=1.4e-60

Best Hits

Swiss-Prot: 69% identical to METK_BACV8: S-adenosylmethionine synthase (metK) from Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)

KEGG orthology group: K00789, S-adenosylmethionine synthetase [EC: 2.5.1.6] (inferred from 69% identity to bvu:BVU_1184)

Predicted SEED Role

"S-adenosylmethionine synthetase (EC 2.5.1.6)" in subsystem Methionine Biosynthesis or Methionine Degradation or Quorum Sensing: Autoinducer-2 Synthesis (EC 2.5.1.6)

MetaCyc Pathways

• superpathway of L-cysteine biosynthesis (mammalian) (4/5 steps found)
• S-adenosyl-L-methionine biosynthesis (1/1 steps found)
• S-adenosyl-L-methionine salvage II (2/3 steps found)
• L-methionine degradation I (to L-homocysteine) (2/3 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (6/9 steps found)
• S-adenosyl-L-methionine salvage I (2/4 steps found)
• aspartate superpathway (17/25 steps found)
• L-cysteine biosynthesis VI (reverse transsulfuration) (4/7 steps found)
• ethene biosynthesis I (plants) (1/3 steps found)
• 2'-deoxymugineic acid phytosiderophore biosynthesis (1/4 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• L-methionine salvage cycle I (bacteria and plants) (4/12 steps found)
• L-methionine salvage cycle III (3/11 steps found)
• L-methionine salvage cycle II (plants) (2/11 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.6

Sequence Analysis Tools

See A0A1X9YWZ2 at UniProt or InterPro

Protein Sequence (434 amino acids)

>CA264_19025 methionine adenosyltransferase (Pontibacter actiniarum KMM 6156, DSM 19842)
MPYLFTSESVSEGHPDKVADQISDALLDEFLKQDPQSKVACETLVTTGLVVLSGEVKTEA
YVDVQKVAREVIKRIGYTKSEYMFDADACGVISAIHEQSSDINQGVERANPEEQGAGDQG
MMFGYATNETDNYMPLALSISHLLLQELSAIRKEGREMTYLRPDAKSQVTIRYNDNDVPE
KIDTIVISTQHDEFVPAEGDTAEAKDAAEKKMVAKIKDDVDSILIPRVLEKLPERTQKLF
NSDIIYHINPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDSSKVDRSAAY
AARHIAKNLVAAGVANQALVQVAYAIGVAKPVGLYVTTYGSTKVNDANGHLMSDGEIAEK
VGKLFDMRPYAIVQRYGLQNPIFSETAAYGHMGRTPGKKVVEVSVNGKKETREFETFTWE
KLDYVDRIKAEFGL