Protein Info for CA264_18790 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: thymidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 63% identical to KITH_BACTN: Thymidine kinase (tdk) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K00857, thymidine kinase [EC: 2.7.1.21] (inferred from 69% identity to lby:Lbys_3249)

MetaCyc: 37% identical to cytosolic thymidine kinase monomer (Homo sapiens)
Deoxynucleoside kinase. [EC: 2.7.1.145, 2.7.1.21]; 2.7.1.145,2.7.1.21 [EC: 2.7.1.145, 2.7.1.21]

Predicted SEED Role

"Thymidine kinase (EC 2.7.1.21)" in subsystem Folate Biosynthesis (EC 2.7.1.21)

MetaCyc Pathways

superpathway of pyrimidine deoxyribonucleoside salvage (9/9 steps found)
purine deoxyribonucleosides salvage (6/6 steps found)
pyrimidine deoxyribonucleosides salvage (5/5 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.145 or 2.7.1.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YWY4 at UniProt or InterPro

Protein Sequence (198 amino acids)

>CA264_18790 thymidine kinase (Pontibacter actiniarum KMM 6156, DSM 19842)
MFIEPRVGNKNHANRRGWIEVICGSMFSGKTEELIRRLNRARIAKQKIEIFKPTVDKRYH
EEDVVSHNANSIRSTPIDFAQDMLLLGGSCDVVGIDEAQFFDEGLAEVCVKLANSGVRVI
AAGLDMDYQGKPFGPMPALMSVAEYVTKVHAVCVQCGDIANYSFRNAADEKQVLLGESDS
YEARCRHCFTEGMKGKKS