Protein Info for CA264_18485 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: 2-oxoglutarate dehydrogenase subunit E1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 918 PF16078: 2-oxogl_dehyd_N" amino acids 6 to 42 (37 residues), 44.5 bits, see alignment (E = 1.7e-15) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 8 to 915 (908 residues), 1067.7 bits, see alignment E=0 PF00676: E1_dh" amino acids 197 to 513 (317 residues), 189.9 bits, see alignment E=1.1e-59 PF02779: Transket_pyr" amino acids 583 to 776 (194 residues), 138.6 bits, see alignment E=3.6e-44 PF16870: OxoGdeHyase_C" amino acids 782 to 916 (135 residues), 153.6 bits, see alignment E=7e-49

Best Hits

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 72% identity to chu:CHU_3362)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YWT3 at UniProt or InterPro

Protein Sequence (918 amino acids)

>CA264_18485 2-oxoglutarate dehydrogenase subunit E1 (Pontibacter actiniarum KMM 6156, DSM 19842)
MDKYTYIANAHGDYIDGLYKSYQQDPESVDAGWRKFFEGFEFATAYGENGHEATEGVAAA
PAKGAVAAGESEKEVAVRNLIHAYRTRGHLRSITNPVRARKDRKARLDLADFGLTDADLN
TVFQVGEIIGLGPATLRDIEAALKKIYEGAIGFEYMYIRDPEVLEWFKEKVEKDSLNFNP
SIDFKKRILSKLNEAVVFENFLHTKFLGQKRFSLEGGETTIPALDAIIDRGSELGVEEVV
IGMAHRGRLNVLANIMGKTYEQIFSEFEGTAVPDLTMGDGDVKYHMGYSSEVVTPSGNKV
NLKLAPNPSHLEAVNPVVEGFVRAKIDTLYNKDADKILPILIHGDAAVAGQGIVYEVTQM
ANLEGYNTGGTIHFVINNQVGFTTDFEDARSSIYCTDVAKILDAPVLHVNGDDPEAVVFA
MRFAMEYRQKVNNDIFIDMVCYRRHGHNESDEPKFTQPQLYNLISKHANPREVYNKDLIS
RGEVDADLAKSMDKEFRKMLQDRLDMVKQKPLPYNYQQMEKEWQELRRSKPEDFNQSPET
GISAEAVETVGKALTTLPQGFKPLKQIEKLIKERKEMFFETKQLNWAAGELLAYGSVLLD
GHIVRFSGQDVQRGTFSHRHAVLHDAVTSAPYNNLNHMAEQQGSFEIYNSLLSEYGVLGF
EFGYAMANPNALVIWEAQFGDFANGAQVMIDQFVTATESKWQRMNGLVMLLPHGYEGQGP
EHSNARPERFLQLAAENNIFVTYITTPANLFHFMRRQLALPFRKPAVNMSPKSLLRHPLV
VSPVEDFTSGGFKEVIGDSYVTAKSVKKVLLCSGKVYFDLLEEQQKNERKDVAIIRMEQL
APFPKVQLEAELKKYKNAKIYWVQEEPENMGAWTYILRIMRSQVEDVVARKASASPATGY
LKVHVKEQQELVDRAFAI