Protein Info for CA264_18410 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: glycine dehydrogenase (aminomethyl-transferring)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 972 transmembrane" amino acids 330 to 351 (22 residues), see Phobius details PF02347: GDC-P" amino acids 13 to 443 (431 residues), 595.4 bits, see alignment E=1.3e-182 amino acids 479 to 743 (265 residues), 40.9 bits, see alignment E=2.6e-14 TIGR00461: glycine dehydrogenase" amino acids 14 to 955 (942 residues), 1486.2 bits, see alignment E=0 PF01212: Beta_elim_lyase" amino acids 544 to 720 (177 residues), 27.8 bits, see alignment E=3.2e-10 PF21478: GcvP2_C" amino acids 784 to 904 (121 residues), 205.4 bits, see alignment E=4.1e-65

Best Hits

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 61% identity to cat:CA2559_07640)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YWM8 at UniProt or InterPro

Protein Sequence (972 amino acids)

>CA264_18410 glycine dehydrogenase (aminomethyl-transferring) (Pontibacter actiniarum KMM 6156, DSM 19842)
MIFKTKPADVFKERHNGPDKEQMQDMLRTIGVETLDQLIEETVPAAIRLKKPLNLPAALS
EKDFLNKFSQIAKQNKVYKSYIGLGYNDTIMPPVILRNIMENPGWYTAYTPYQAEIAQGR
LEALINYQTMVMDLTGMEIANASLLDEGTAAAEAMAMFFSQRKGTRKNATRFFVSNQVLP
QTIDILLTRATPLDIELVIGDHREANLQDETLFGAIVQYPAADGAIFDYTDFISKAHEQG
MMVAVAADILSLTLLTPPGEMGADAVVGTTQRFGVPMGFGGPHAGYFATRDAFKRVIPGR
IIGVSVDAAGNKAYRMALQTREQHIRREKATSNICTAQVLLAVIAGMYAVYHGPRRLKYI
GLNTHALAQQLENGLKALGFAQQNEQYFDTLKVVVESADMQQAIRKEAEAAGINFRYFDS
TNIGISINQNTDLQDVKAILAVFAKVAGKSADVLNIDTLPEDTDVTWADSLIRKSAYMEQ
EVFNRHHSEHEILRYMKHLENKDISLVHSMISLGSCTMKLNATAEMIPVTWPEIGQLHPF
APADQTQGYKQIFTDLEAWLCEITGFDGVSLQPNSGAQGEYAGLMVIRAYHESRGEGHRN
ISLIPSSAHGTNPASAVMAGMKVVIVKCDEKGNIDVADLRAKAEQYKNELSCLMVTYPST
HGVYEESIIEICQIIHDNGGRVYMDGANMNAQVGLTSPATIGADVCHLNLHKTFCIPHGG
GGPGVGPIGVVADLVPFLPGHAVVKTGGDTAIHAVSAAPWGSASILPISYAYIAMMGGEG
LTEATKVAILNANYIKARLEKHYPVLYVGKNGRCAHEMILDCREFKKAGVEVEDIAKRLM
DYGFHAPTVSFPVAGTLMVEPTESEAQEELDRFCDVMISIREEIREVEEGKADQKNNVLK
NAPHTARVVMVENWDRPYSREKAVFPMPYLRDSKVWPTVSRIDSAYGDRNLVCSCAPIEA
YNENNNEMVAVG