Protein Info for CA264_18290 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: NADH dehydrogenase subunit D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00346: Complex1_49kDa
  • amino acids 144 to 403 (260 residues), 277.8 bits, E=3.9e-87

Best Hits

Swiss-Prot: 71% identical to NUOD1_CYTH3: NADH-quinone oxidoreductase subunit D 1 (nuoD1) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K00333, NADH dehydrogenase I subunit D [EC: 1.6.5.3] (inferred from 72% identity to sli:Slin_5351)

MetaCyc: 42% identical to NADH-ubiquinone oxidoreductase 49kDa subunit (Arabidopsis thaliana col)
NADH-DEHYDROG-A-RXN [EC: 7.1.1.2]

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain D (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration I (cytochrome c) (3/4 steps found)
• aerobic respiration III (alternative oxidase pathway) (2/3 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• Fe(II) oxidation (2/6 steps found)
• NAD(P)/NADPH interconversion (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3 or 7.1.1.2

Sequence Analysis Tools

See A0A1X9YWK5 at UniProt or InterPro

Protein Sequence (403 amino acids)

>CA264_18290 NADH dehydrogenase subunit D (Pontibacter actiniarum KMM 6156, DSM 19842)
MSQSTIYKNYLLQSEPNKFSQDALKAGEMIVNMGPQHPSTHGVLRLEVVTDGEIIQEVVP
HIGYLHRCFEKHAESMAYNQTIPYVDRMDYLAAMNSEHVWCMGVEKLMGITDQIPKRVEY
IRVLVTELNRIASHFVAIGTYAIDIGAFTPFLWLLRDREHIQRLLEWVCGARMLYNYIWV
GGLYYDLPIGFEERCREFIEYLQPKLDELDTILLSNKIFIDRTANVGVLPLDVAINYACS
GPMLRGSGLKHDLRRVDGYSVYPELDFDVPIGQGLAGTTGDCWDRNYVRALECRESVKII
RQCLDRLTGDYKRTPDFDPQAACPKKIRMTGSKELYFRGETPRGELGYYFRTTDKSDVPF
RAKGRAPSFVNLSVLHEISRGCMVADLIAIVGSVDIVLGEVDR