Protein Info for CA264_18210 in Pontibacter actiniarum KMM 6156, DSM 19842
Annotation: L-serine dehydratase, iron-sulfur-dependent subunit alpha
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 42% identical to SDHA_PEPAS: L-serine dehydratase, alpha chain (sdhA) from Peptoniphilus asaccharolyticus
KEGG orthology group: K01752, L-serine dehydratase [EC: 4.3.1.17] (inferred from 74% identity to mtt:Ftrac_1933)MetaCyc: 42% identical to L-serine dehydratase alpha subunit (Peptoniphilus asaccharolyticus)
L-serine ammonia-lyase. [EC: 4.3.1.17]
Predicted SEED Role
"L-serine dehydratase, alpha subunit (EC 4.3.1.17)" in subsystem Glycine and Serine Utilization or Pyruvate Alanine Serine Interconversions (EC 4.3.1.17)
MetaCyc Pathways
- D-serine degradation (3/3 steps found)
- L-cysteine degradation II (3/3 steps found)
- L-serine degradation (3/3 steps found)
- glycine degradation (3/3 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (11/15 steps found)
- L-tryptophan degradation II (via pyruvate) (2/3 steps found)
- glycine betaine degradation III (4/7 steps found)
- L-methionine biosynthesis II (3/6 steps found)
- felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
- L-mimosine degradation (4/8 steps found)
- glycine betaine degradation I (4/8 steps found)
- glutathione-mediated detoxification I (2/8 steps found)
- purine nucleobases degradation II (anaerobic) (13/24 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.3.1.17
Use Curated BLAST to search for 4.3.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9YWA7 at UniProt or InterPro
Protein Sequence (303 amino acids)
>CA264_18210 L-serine dehydratase, iron-sulfur-dependent subunit alpha (Pontibacter actiniarum KMM 6156, DSM 19842) MSLLFTDFKSWEKHCAETGEPLYQPVLEYEVEQKGRSEAFIWENIANAFEVMKDAVQTGL TEDMKSRSGMVNNSAKKVAKSPVTVLSPEFQLLVARALGAKEVNSCMGRVVAAPTAGASG ILPGTLTTLQELHGLEDRLIHEGLLVAAGIALIIEQNASLAGAVGGCQAETGSAAAMAAG AIVYCLGGDVKQVFNAVAITIQCMLGLVCDPVAGLVEVPCIVRNASAAAIAFSSAQLGIA GVDPVIPVDQCVAALGEVGESMERKYKETAEGGLANTPRAREIENFVLVQDVEILPDEDE ADS