Protein Info for CA264_17995 in Pontibacter actiniarum KMM 6156, DSM 19842
Annotation: 2-hydroxymuconic semialdehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to AL8A1_MOUSE: 2-aminomuconic semialdehyde dehydrogenase (Aldh8a1) from Mus musculus
KEGG orthology group: K00151, 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC: 1.2.1.60] (inferred from 68% identity to fte:Fluta_1400)MetaCyc: 54% identical to 2-hydroxymuconate-6-semialdehyde dehydrogenase (Paenibacillus sp. JJ-1b)
RXN-8527 [EC: 1.2.1.85]
Predicted SEED Role
"5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (EC 1.2.1.60)" in subsystem 4-Hydroxyphenylacetic acid catabolic pathway or Aromatic amino acid degradation or Central meta-cleavage pathway of aromatic compound degradation (EC 1.2.1.60)
MetaCyc Pathways
- protocatechuate degradation III (para-cleavage pathway) (2/5 steps found)
- catechol degradation to 2-hydroxypentadienoate II (1/4 steps found)
- 4-amino-3-hydroxybenzoate degradation (2/6 steps found)
- 2,3-dihydroxybenzoate degradation (1/5 steps found)
- 4-hydroxyphenylacetate degradation (3/8 steps found)
- catechol degradation II (meta-cleavage pathway) (1/7 steps found)
- meta cleavage pathway of aromatic compounds (1/10 steps found)
- toluene degradation IV (aerobic) (via catechol) (1/13 steps found)
- superpathway of aerobic toluene degradation (4/30 steps found)
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate (8/42 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.60 or 1.2.1.85
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9YWC1 at UniProt or InterPro
Protein Sequence (481 amino acids)
>CA264_17995 2-hydroxymuconic semialdehyde dehydrogenase (Pontibacter actiniarum KMM 6156, DSM 19842) MNQLQNYINGQLVAPAAGQYIDNYNPATGEVYSLIPDSDEQDVEQAVQAAQAAFPAWAKT SAEKRGRILMKIADLIDENLERLAEAESVDNGKPLKLARTVDIPRASSNMRFYGTAIQHF ASEAHYMDGTEAINYTVRHPHGVAGCISPWNLPLYLFTWKIAPALAAGNCVVAKPSEVTP MTAYLLSEICMEAGLPAGVLNIVHGYGHKVGAAMVAHPKVPVISFTGGTATGRSIAATAA PMFKKLSLELGGKNPNIIFADCDFNKALHTSIHSSFANQGQICLCGSRIFIERPLYEKFR DAFVEKVKTLTVGDPLEDGSKQGAVVSEQHMQKVLSYIELAKQEGGTILTGGHQVQVEGR CAKGWFISPTVIEGLPYNCRTNTEEIFGPVVTLTPFDTEEEVIQYANCTDYGLSATIWTQ NLQRAHRVAHQVHSGIIWVNTWLLRDLRTPFGGMKNSGVGREGGFEALNFFTEPQNVCVK L