Protein Info for CA264_17915 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: LPS biosynthesis protein WbpP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05368: NmrA
  • amino acids 17 to 135 (119 residues), 28.1 bits, E=4.7e-10
• PF01370: Epimerase
  • amino acids 17 to 257 (241 residues), 191.1 bits, E=7.8e-60
• PF01073: 3Beta_HSD
  • amino acids 17 to 246 (230 residues), 82.7 bits, E=8.6e-27
• PF16363: GDP_Man_Dehyd
  • amino acids 17 to 320 (304 residues), 179.5 bits, E=4.6e-56
• PF02719: Polysacc_synt_2
  • amino acids 17 to 246 (230 residues), 59.8 bits, E=8.8e-20
• PF07993: NAD_binding_4
  • amino acids 18 to 169 (152 residues), 31 bits, E=5.2e-11
• PF13460: NAD_binding_10
  • amino acids 20 to 165 (146 residues), 42.6 bits, E=2.2e-14

Best Hits

KEGG orthology group: K01784, UDP-glucose 4-epimerase [EC: 5.1.3.2] (inferred from 62% identity to gfo:GFO_2041)

Predicted SEED Role

"UDP-glucose 4-epimerase (EC 5.1.3.2)" in subsystem Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway or Lactose and Galactose Uptake and Utilization or N-linked Glycosylation in Bacteria or Rhamnose containing glycans or linker unit-arabinogalactan synthesis (EC 5.1.3.2)

MetaCyc Pathways

• colanic acid building blocks biosynthesis (9/11 steps found)
• UDP-α-D-galactose biosynthesis (1/1 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis I (1/1 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-α-D-galactofuranose biosynthesis (1/2 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (4/7 steps found)
• D-galactose detoxification (1/3 steps found)
• UDP-sugars interconversion (4/9 steps found)
• stachyose degradation (1/7 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
• mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (1/18 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.2

Use Curated BLAST to search for 5.1.3.2

Sequence Analysis Tools

See A0A1X9YWE4 at UniProt or InterPro

Protein Sequence (341 amino acids)

>CA264_17915 LPS biosynthesis protein WbpP (Pontibacter actiniarum KMM 6156, DSM 19842)
MYDFPYHDKPLSNTSFLVTGGAGFIGSNLVEYLLKYKAGKVRVLDNFSNGYRKNIEQFLD
NPAFELMEGDIRDPQTCMEACAGMDVVLHQAALGSVPRSINDPITSNDVNVGGFVNMLTA
AKENNIKRFVYAASSSTYGDSKELPKVEDRIGKPLSPYAVTKYANELYADVFGKTYGMEI
IGLRYFNIFGPRQDPNGAYAAVIPLFIDALIHNRSPKINGDGGQTRDFTFIENCVQANIK
AALVDNAEAVNQVYNIAVGDRTSLLEMFHILKKAAAVDVEPVHGPDRAGDIRDSLADISK
AKGLLQYEPKVRIEEGLQRTFDWFKENQEFIYRDTKAAAAH