Protein Info for CA264_17760 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: leucine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 PF02812: ELFV_dehydrog_N" amino acids 24 to 143 (120 residues), 105.3 bits, see alignment E=2e-34 PF00208: ELFV_dehydrog" amino acids 153 to 211 (59 residues), 28.4 bits, see alignment E=1.3e-10 amino acids 223 to 324 (102 residues), 45.9 bits, see alignment E=5.9e-16

Best Hits

Swiss-Prot: 59% identical to DHLE_THEIN: Leucine dehydrogenase (ldh) from Thermoactinomyces intermedius

KEGG orthology group: K00263, leucine dehydrogenase [EC: 1.4.1.9] (inferred from 63% identity to mtt:Ftrac_1913)

Predicted SEED Role

"Leucine dehydrogenase (EC 1.4.1.9)" in subsystem Branched-Chain Amino Acid Biosynthesis or Leucine Degradation and HMG-CoA Metabolism (EC 1.4.1.9)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YW91 at UniProt or InterPro

Protein Sequence (366 amino acids)

>CA264_17760 leucine dehydrogenase (Pontibacter actiniarum KMM 6156, DSM 19842)
MVELKEVELKKDKSVFDQISEHNHEKVVFCHDKETGLKAIIGIHNTVLGPALGGTRMWSY
ASEAEALDDVLRLSRGMTYKAAISGLNLGGGKAVIIGDAKKDKNEAFLRRYGRFIKNLNG
AYITAEDVGTTTKDMEFIRMETEHVAGLPESMGGSGDPSPVTAYGTYMGMKAAAKKAFGS
DSLEGKKISVQGVGHVGGYLVELLAKENAEIFITDIYEDRLREVSNKYGAKVVSMDEIYD
LDVDIYSPCALGGTINDNTLNRLKCQVIAGSANNQLRDEQVHGPALVEKGIVYAPDFLIN
AGGLINVYSELIGYNRESAYAQTERIYGYTLDIFNLAERENIHNQAAAMQMAKQRIESIG
KVRSTY