Protein Info for CA264_17360 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: geranyl transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00348: polyprenyl_synt
  • amino acids 25 to 261 (237 residues), 255.3 bits, E=2.6e-80

Best Hits

KEGG orthology group: K13789, geranylgeranyl diphosphate synthase, type II [EC: 2.5.1.1 2.5.1.10 2.5.1.29] (inferred from 52% identity to bth:BT_2058)

Predicted SEED Role

"Dimethylallyltransferase (EC 2.5.1.1) / Geranyltranstransferase (farnesyldiphosphate synthase) (EC 2.5.1.10) / Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.29)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis or Carotenoids or Polyprenyl Diphosphate Biosynthesis (EC 2.5.1.1, EC 2.5.1.10, EC 2.5.1.29)

MetaCyc Pathways

• polyisoprenoid biosynthesis (E. coli) (5/5 steps found)
• trans, trans-farnesyl diphosphate biosynthesis (2/2 steps found)
• geranyl diphosphate biosynthesis (1/1 steps found)
• geranylgeranyl diphosphate biosynthesis (1/1 steps found)
• (3R)-linalool biosynthesis (1/2 steps found)
• (3S)-linalool biosynthesis (1/2 steps found)
• linalool biosynthesis I (1/2 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (8/12 steps found)
• all-trans-farnesol biosynthesis (2/4 steps found)
• methyl phomopsenoate biosynthesis (2/4 steps found)
• ophiobolin F biosynthesis (1/3 steps found)
• plaunotol biosynthesis (1/3 steps found)
• superpathway of linalool biosynthesis (1/3 steps found)
• taxadiene biosynthesis (engineered) (8/13 steps found)
• ipsdienol biosynthesis (1/4 steps found)
• bisabolene biosynthesis (engineered) (2/6 steps found)
• mono-trans, poly-cis decaprenyl phosphate biosynthesis (1/5 steps found)
• stellatic acid biosynthesis (3/8 steps found)
• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (4/10 steps found)
• superpathway of chorismate metabolism (39/59 steps found)
• paspaline biosynthesis (1/6 steps found)
• superpathway of ubiquinol-8 biosynthesis (early decarboxylation) (5/12 steps found)
• superpathway of phylloquinol biosynthesis (7/15 steps found)
• brassicicene C biosynthesis (1/7 steps found)
• fusicoccin A biosynthesis (1/8 steps found)
• viridicatumtoxin biosynthesis (1/9 steps found)
• superpathway of ergosterol biosynthesis II (7/26 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)
• superpathway of ergosterol biosynthesis I (3/26 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (20/56 steps found)
• superpathway of cholesterol biosynthesis (3/38 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.1, 2.5.1.10, 2.5.1.29

Use Curated BLAST to search for 2.5.1.1 or 2.5.1.10 or 2.5.1.29

Sequence Analysis Tools

See A0A1X9YVX5 at UniProt or InterPro

Protein Sequence (324 amino acids)

>CA264_17360 geranyl transferase (Pontibacter actiniarum KMM 6156, DSM 19842)
MDISTLSEKINHTLSTLRYGENPAELYEPIRYIMALGGKRIRPLLVLLGAEMFDEDVEKA
LLPAAAVEVFHNFTLMHDDIMDKAPLRRGQQTVHEKWNANTAILSGDVMLVRAYELLLGV
EPGKLALVLRLFSRTAAEVCEGQQLDMNFERREQVSREEYIHMITLKTAVLLGFSLELGA
ILQGAPEADAEHLKAFGDNVGIAFQLRDDLLDVYGDQTKFGKQVGGDILSDKKTFLMLTA
LEQANEEQLHVINNWRNQPADCIAADKVKAITGIYDQLGVRQQTEQQIEVYFQKAMQHFD
AVQLPEARKAAIRALTLQLMERDS