Protein Info for CA264_17070 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: NAD(P)-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 45 to 231 (187 residues), 166.6 bits, E=7.5e-53
• PF08659: KR
  • amino acids 47 to 208 (162 residues), 38.1 bits, E=2.3e-13
• PF13561: adh_short_C2
  • amino acids 53 to 283 (231 residues), 196.4 bits, E=8.9e-62

Best Hits

Swiss-Prot: 61% identical to GS39_BACSU: General stress protein 39 (ydaD) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 66% identity to ddr:Deide_2p02251)

MetaCyc: 53% identical to aldehyde reductase (chloroplastic) (Arabidopsis thaliana col)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]

Predicted SEED Role

"oxidoreductase, short chain dehydrogenase/reductase family"

MetaCyc Pathways

• methylglyoxal degradation III (1/2 steps found)
• glycerol degradation to butanol (11/16 steps found)
• pyruvate fermentation to butanol I (5/8 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• D-xylose degradation to ethylene glycol (engineered) (1/4 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• detoxification of reactive carbonyls in chloroplasts (4/10 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• traumatin and (Z)-3-hexen-1-yl acetate biosynthesis (3/12 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (6/17 steps found)
• superpathway of lipoxygenase (4/22 steps found)
• superpathway of pentose and pentitol degradation (7/42 steps found)

KEGG Metabolic Maps

• Caprolactam degradation
• Fructose and mannose metabolism
• Galactose metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Pentose and glucuronate interconversions
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.2 or 1.1.1.21

Sequence Analysis Tools

See A0A1X9YYV4 at UniProt or InterPro

Protein Sequence (288 amino acids)

>CA264_17070 NAD(P)-dependent oxidoreductase (Pontibacter actiniarum KMM 6156, DSM 19842)
MKTMENKPKSFPGQRQEQPGDQYKMTPEPEIIKDSYKGSGKLKDKVALITGGDSGIGRSV
AVHFAREGADVAIVYLEEDKDAQDTKSMVEKEGRKCLLIAGDVGGEDFCKEAVQRTVKEL
GKLDILVNNAGEQHEQHDIRDISAEQLQRTFTTNIFAMFYFVKEALNHMKEGSAIINTAS
VTAYHGNKLLLDYSSTKGAIVAFTRTLAQMVADKKIRVNGVAPGPIWTPLIPASFNEDKV
KSFGQSTPLKRAGQPSEVAPAYVYLASEDSTYTIAEMLHVNGGEMVTT