Protein Info for CA264_16765 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: coproporphyrinogen III oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 375 TIGR00539: putative oxygen-independent coproporphyrinogen III oxidase" amino acids 4 to 347 (344 residues), 281.8 bits, see alignment E=4.2e-88 PF04055: Radical_SAM" amino acids 6 to 166 (161 residues), 95.2 bits, see alignment E=2.6e-31

Best Hits

KEGG orthology group: K02495, oxygen-independent coproporphyrinogen III oxidase [EC: 1.3.99.22] (inferred from 56% identity to dfe:Dfer_5773)

Predicted SEED Role

"Hypothetical radical SAM family enzyme, NOT coproporphyrinogen III oxidase, oxygen-independent" in subsystem Heat shock dnaK gene cluster extended or Heme and Siroheme Biosynthesis

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.22

Use Curated BLAST to search for 1.3.99.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YVM5 at UniProt or InterPro

Protein Sequence (375 amino acids)

>CA264_16765 coproporphyrinogen III oxidase (Pontibacter actiniarum KMM 6156, DSM 19842)
MAGIYLHIPFCKKACHYCDFHFSTSMALKTDLVQAMVRELELRQGYLQGQEVGTIYFGGG
TPSLLTRQELQLLLATIKRLFIVSDDAEITLEANPDDLRPEKLQELQAAGINRLSIGLQS
FHEPHLQLMNRAHTASESINCVKDAQAAGFSNITVDLIYGVPAPDHTVWQQDLDTLFSLG
VQHVSCYALTIEPDTALGRWSKKGKFKPAEDEFTAQQFEMLLEQMQQQAYVQYEISNFSK
PGHESRHNSNYWRGVHYLGIGPSAHSFNGPTRQYNVSHNKKYIDALQQGAVPFELEELTL
ADQANDYLLTTLRTIWGCDLGKLRQDYHYDLAARHAAYLQELQHMGLASVQHDVLYLTDR
GKLLADQITLELFMS