Protein Info for CA264_15585 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: short-chain dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08659: KR
  • amino acids 10 to 174 (165 residues), 46.1 bits, E=1.4e-15
• PF00106: adh_short
  • amino acids 10 to 201 (192 residues), 163.3 bits, E=1.2e-51
• PF01370: Epimerase
  • amino acids 11 to 175 (165 residues), 30 bits, E=8.6e-11
• PF13561: adh_short_C2
  • amino acids 15 to 200 (186 residues), 115.2 bits, E=9e-37

Best Hits

KEGG orthology group: K07124, (no description) (inferred from 59% identity to cyc:PCC7424_4642)

Predicted SEED Role

"3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 1.1.1.100)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• oleate biosynthesis IV (anaerobic) (13/14 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (17/20 steps found)
• biotin biosynthesis I (13/15 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (8/9 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (13/16 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• 8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
• (5Z)-dodecenoate biosynthesis I (5/6 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (4/5 steps found)
• cis-vaccenate biosynthesis (4/5 steps found)
• fatty acid elongation -- saturated (4/5 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (9/12 steps found)
• palmitate biosynthesis III (21/29 steps found)
• (5Z)-dodecenoate biosynthesis II (4/6 steps found)
• stearate biosynthesis II (bacteria and plants) (4/6 steps found)
• anteiso-branched-chain fatty acid biosynthesis (24/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (24/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (24/34 steps found)
• petroselinate biosynthesis (3/6 steps found)
• stearate biosynthesis IV (3/6 steps found)
• 2-allylmalonyl-CoA biosynthesis (2/8 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• tetradecanoate biosynthesis (mitochondria) (12/25 steps found)
• mycolate biosynthesis (23/205 steps found)
• superpathway of mycolate biosynthesis (24/239 steps found)

KEGG Metabolic Maps

• Biosynthesis of unsaturated fatty acids
• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100

Use Curated BLAST to search for 1.1.1.100

Sequence Analysis Tools

See A0A1X9YYT8 at UniProt or InterPro

Protein Sequence (266 amino acids)

>CA264_15585 short-chain dehydrogenase (Pontibacter actiniarum KMM 6156, DSM 19842)
MAEEQKQKYTALITGASGGIGLELAELFARDGHNLVLVARSEDKLNSLALRYAIKYKVYT
KVVAQDLSKADGPEKVFAALKQEGVQVDVLVNNAGFGNFGAFRETDLQKELDMMQLNMVS
LTHLCKLFLHQLRDGQHGRILNVSSTAAFPPGPYMAVYYASKAYVQSFTEALAAELEDEN
VSVTALCPGPTETEFQQAANLHESGLFSSQLVADARSVAKAGYSGMMAGEVVVIPGIQNK
LTAFSTRLVPRSVLRQLVKKIQGKRA