Protein Info for CA264_14900 in Pontibacter actiniarum KMM 6156, DSM 19842

Updated annotation (from data): uvrA paralog in Bacteroidetes
Rationale: Very important for resisting cisplatin. Both the "standard" uvrA and this gene were important for cisplatin resistance. (SEED_correct)
Original annotation: excinuclease ABC subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 935 TIGR00630: excinuclease ABC subunit A" amino acids 17 to 920 (904 residues), 1117.2 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 145 to 254 (110 residues), 70.7 bits, see alignment E=4.5e-23 PF17755: UvrA_DNA-bind" amino acids 303 to 366 (64 residues), 46.9 bits, see alignment 1.5e-15

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 68% identity to chu:CHU_3698)

Predicted SEED Role

"Excinuclease ABC subunit A paralog in greater Bacteroides group" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YUU2 at UniProt or InterPro

Protein Sequence (935 amino acids)

>CA264_14900 uvrA paralog in Bacteroidetes (Pontibacter actiniarum KMM 6156, DSM 19842)
MANTSADKLDELDARQNIIIKGARVHNLKNLSVALPRNKFIVITGLSGSGKSSLAFDTLY
AEGQRMYVESLSSYARQFLGRMDKPDVDYIKGISPAIAIEQKVSIKNNRSTVGTSTEIYD
YLKLLYARIGKTYSPVSGEVVKKDSVTDVVNFIFSLEDEARVMILAPLHQHQERTLAKEL
DLLLQKGYSRIYANEQVYFIEELLEEKKPKLGKEVFILVDRAVIYKSDEDLAFRISDSVQ
TAFFEGHGECRVLYGNGEERVFSDRFELDGMVFEEPSVNFFSFNNPYGACQTCEGFGSVL
GIDPDLVIPDKSLTVYEGAIAPWRTDKMNEWLQPLLKNGIRFDFPIHRPYNELTEAEQEL
LWTGNKYFSGLNAFFKEIQSQTHKIQYRVMLSRYRGRTTCPECRGSRLRKDASYVKVGGK
SITDLVLMPITQVLPFFQNLELTEHEHNVAERLVTEVSNRLGYLQRVGLGYLTLNRLSNT
LSGGESQRINLATSLGSALVGSMYILDEPSIGLHPKDSEQLIGVLRSLQQIGNTVIVVEH
EEEMMKAADQLIDIGPEAGSGGGNLMFQGSFEEMTQRADTYTSKYLSGKMEVPVPAQRRK
WRNAIEIIGARENNLKNLSVKVPLGVMTVVTGVSGSGKSTLIKKILAPAMQKLHGSTAEA
TGKFDKLAGDYNKIEHVEFVDQNPIGKSSRSNPVTYVKAYDAIRTLYADQPLAKSRGFKP
SHFSFNIEGGRCEVCQGEGQVKIEMQFMADIYLTCESCHGQRFKQDVLDIKYKDKSISDV
LEMTIADSIDFFADQPKIIEKLKPLNDVGLGYIRLGQSSNTLSGGEAQRVKLASFLTKGA
QPHQENILFIFDEPSTGLHFHDISKLLTSINALIENGNTVVIIEHNMDIVKCADWIIDLG
PEGGTNGGHLLFEGTPEEMAKLEDNDTARFLKEKL