Protein Info for CA264_14540 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: NADP-dependent malic enzyme

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00390: malic
  • amino acids 18 to 149 (132 residues), 97 bits, E=1.8e-31
• PF03949: Malic_M
  • amino acids 164 to 354 (191 residues), 72.3 bits, E=6.3e-24
• PF01515: PTA_PTB
  • amino acids 427 to 745 (319 residues), 321.5 bits, E=1e-99

Best Hits

KEGG orthology group: K00029, malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC: 1.1.1.40] (inferred from 70% identity to chu:CHU_0027)

Predicted SEED Role

"NADP-dependent malic enzyme (EC 1.1.1.40)" in subsystem Pyruvate metabolism I: anaplerotic reactions, PEP (EC 1.1.1.40)

MetaCyc Pathways

• gluconeogenesis I (11/13 steps found)
• C4 photosynthetic carbon assimilation cycle, NADP-ME type (4/7 steps found)
• C4 photosynthetic carbon assimilation cycle, PEPCK type (9/14 steps found)
• methylgallate degradation (2/6 steps found)
• protocatechuate degradation I (meta-cleavage pathway) (3/8 steps found)
• superpathway of vanillin and vanillate degradation (3/10 steps found)
• syringate degradation (3/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of terpenoids and steroids
• Carbon fixation in photosynthetic organisms
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.40

Sequence Analysis Tools

See A0A1X9YYA3 at UniProt or InterPro

Protein Sequence (756 amino acids)

>CA264_14540 NADP-dependent malic enzyme (Pontibacter actiniarum KMM 6156, DSM 19842)
MKVNKEDALNYHMEGKPGKIEVVPTKMVSTQHDLALAYSPGVAEPCKEIYANKDNVYKYT
AKGNLVGVISNGTAVLGLGNIGPDASKPVMEGKGVLFKKFAGIDVFDIEIDSTDPEEFVR
IVKSLEPTFGGINLEDIKAPESFKIENALKTQMNIPLMHDDQHGTAIISSAALLNALELV
DKKIGEIKIVVNGAGAAAIACTKLYVALGVKMDNIVMFDKDGIIRPERDDLDIYRAQFVT
TRKINTLAEALTDADVFVGLSAGNVLAPELVKLMAADPIIFALANPDPEIPYDVAMATRE
DLIMATGRSDHPNQVNNVLGFPYIFRGALDVRATEINEEMKLAAVHALAKLAKEPVPELV
HKAYGDNTINFGRTYLIPKPLDPRLITTVSPAVAKAAIESGVARQPITDWEAYEQELKER
IGIDQKLMSRITTQAKKDPKTVVFAEADHYKILKAAQIVKEQRIANPVLLGNPERIEAII
AENNMDLQGVTIIDPFKEDAKREEYAQILFDKRQRKGLTLFDARRLMRDRNYFGSMMLNT
GEADALISGLTRDYSKTMLPALQVVGVEEGINKVAGMYIILGQKEPYFFADTTVNVNPTA
DELVDIIGLTARTVRFFDTEPRVAMLSYSNFGSVRGEIPNKATEAVRKAKQRYPELLIDG
EMQANTALNRNLLREHYPFSELADKGANTLVFPTLASGNIAYKLLQEIGGVEVIGPVLMG
MRKPVHILQLGSSIRDIVNMVSIAVVDAQNYNNQHI