Protein Info for CA264_14480 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: large-conductance mechanosensitive channel

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 149 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 82 to 101 (20 residues), see Phobius details PF01741: MscL" amino acids 3 to 134 (132 residues), 150.4 bits, see alignment E=1.5e-48 TIGR00220: large conductance mechanosensitive channel protein" amino acids 3 to 136 (134 residues), 146.6 bits, see alignment E=2.1e-47

Best Hits

Swiss-Prot: 57% identical to MSCL_PSEF5: Large-conductance mechanosensitive channel (mscL) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

KEGG orthology group: K03282, large conductance mechanosensitive channel (inferred from 58% identity to psa:PST_0946)

Predicted SEED Role

"Large-conductance mechanosensitive channel" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YUH8 at UniProt or InterPro

Protein Sequence (149 amino acids)

>CA264_14480 large-conductance mechanosensitive channel (Pontibacter actiniarum KMM 6156, DSM 19842)
MGFISDFKKFAVKGNVIDLAVAVVIGAAFGAITKSLVDDIIMPPLGLLVSGIDFSSLQVV
LKEAVVENGEVVAKAVTLNYGNFIQVVINFLIIALAIFMLVRTINRLQEKEAAKPAPPVN
KQEVLLAEIRDLLKGQNPSAASEPHDKVV