Protein Info for CA264_14015 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01081: Aldolase
  • amino acids 15 to 195 (181 residues), 109.6 bits, E=7.1e-36

Best Hits

KEGG orthology group: K01625, 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC: 4.1.2.14 4.1.3.16] (inferred from 56% identity to shg:Sph21_0579)

Predicted SEED Role

"4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)" (EC 4.1.2.14, EC 4.1.3.16)

MetaCyc Pathways

• Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
• trans-4-hydroxy-L-proline degradation I (4/5 steps found)
• D-fructuronate degradation (3/4 steps found)
• superpathway of β-D-glucuronosides degradation (5/7 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (12/17 steps found)
• Entner-Doudoroff shunt (1/2 steps found)
• Entner-Doudoroff pathway I (6/9 steps found)
• D-galacturonate degradation I (3/5 steps found)
• D-glucosaminate degradation (1/3 steps found)
• superpathway of hexuronide and hexuronate degradation (6/10 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (2/5 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (3/7 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (8/31 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glyoxylate and dicarboxylate metabolism
• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.14 or 4.1.3.16

Sequence Analysis Tools

See A0A1X9YUE9 at UniProt or InterPro

Protein Sequence (223 amino acids)

>CA264_14015 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase (Pontibacter actiniarum KMM 6156, DSM 19842)
MATDTRQALQQILATPTIPVYYNSNPEECKAVLSACYEGGIRVFEFTDRGAAALDNFKVL
KELAQARYPDLKLGIGTIKDSARAEAYIAAGADFIVCPIMDAAVAQTVQRHELLWIPGCM
TPTEIAQAEKAGAQLVKLFPGSVLGVEFLKAIKALFPDLLFMPTGGVAPTAESIHEWFSA
GVKAVGLGSKLFEPDTTSGSGHAWLSARCRQLLEWAQNNKGGS