Protein Info for CA264_13980 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: alpha-glucuronidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 721 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF03648: Glyco_hydro_67N" amino acids 30 to 151 (122 residues), 90.3 bits, see alignment E=2.3e-29 PF07488: Glyco_hydro_67M" amino acids 155 to 474 (320 residues), 520.1 bits, see alignment E=4.4e-160 PF07477: Glyco_hydro_67C" amino acids 475 to 699 (225 residues), 326.6 bits, see alignment E=1.6e-101

Best Hits

Swiss-Prot: 56% identical to AGUA_CELJU: Extracellular xylan exo-alpha-(1->2)-glucuronosidase (gla67A) from Cellvibrio japonicus (strain Ueda107)

KEGG orthology group: K01235, alpha-glucuronidase [EC: 3.2.1.139] (inferred from 65% identity to rmr:Rmar_1079)

Predicted SEED Role

"Alpha-glucuronidase (EC 3.2.1.139)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 3.2.1.139)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.1.139

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YU89 at UniProt or InterPro

Protein Sequence (721 amino acids)

>CA264_13980 alpha-glucuronidase (Pontibacter actiniarum KMM 6156, DSM 19842)
MKRKPVSLLLLLLFLLSANHRLLAEDGYRLWQRYEQVQDAARLQAYRQALNELVVQGNSP
TLTVAQQELQTGLSSLLGQPLAAVKSPTKQNILVAGTPSGSALVKELATAARLKPLGEEG
YLLLTTAKDGKQYTVIAANTDIGVLYGSFHFLRLLQTQQDIGKLSLASSPKIKHRVLNHW
DNLDRTVERGYSGFSLWDWHRLPGYIDQRYLDYARANASVGINGTVLTNVNANALVLTQD
YLKKVAALADAFRPYGLKVYLTARFSAPIEIGGLKTADPLDPQVQAWWKQKADEIYTLIP
DFGGFLVKANSEGQPGPQNYGRTHADGANMLADAVAPHKGIVMWRAFVYSEDEPDDRAKQ
AYNEFKPLDGQFRDNVLVQVKNGAIDFQPREPFHPLFGAMPKTPLMLELQITQEYLGQGT
TLAYLSPMYKETLASDTYAKGKGTTVAKVVDGSVDKHRLTGIAGVANIGTDRNWTGHQFG
QANWYSFGRLAWDHALSPEAIADEWIKMTFTGEQEFVAPVKNMMMNSHEAVVNYMTPLGL
HHIMGWSHHYGPGPWIKDKHRADWTSVYYHRADEKGIGFDRTASGSNAVNQYFPPVAKEF
GSLKRCPEKYLLWFHHVDWDHQVNSGRTLWNELCYRYSSGVDSVRQMQKTWDSLEGMVDR
ERFSHVKQFLAIQEQEAAWWRDACLLYFQTFSKRPIPQDLEKPAHTLDYYMSLDPQFVPG
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