Protein Info for CA264_13905 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 PF00072: Response_reg" amino acids 7 to 109 (103 residues), 57.3 bits, see alignment E=2.5e-19 PF00512: HisKA" amino acids 186 to 253 (68 residues), 53.1 bits, see alignment E=3.9e-18 PF02518: HATPase_c" amino acids 299 to 406 (108 residues), 94.4 bits, see alignment E=9.3e-31

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YUC3 at UniProt or InterPro

Protein Sequence (410 amino acids)

>CA264_13905 hybrid sensor histidine kinase/response regulator (Pontibacter actiniarum KMM 6156, DSM 19842)
MAEKIKVLLIDDDEDDYIITRDIMDDIPRRNYVLDWTSSFEEALALIREGRHDVYLVDFY
LGAQDGLQLITRAVQEGAKAPFILLTGQSDLETDEKAMRAGALDYLVKGTFNPFDLERSI
RYSIEHAMSLAEIQTLNEELEQRVEARTQELAEAIRKLENTNRSLYEAQQEIHKALQKEK
ELHELKSRFVTIASHEFRTPLSTVLSSASLISKYKTEADDEKRQKHVERIKSSVSNLTNI
LNDFLSISKAEEGKIYNVPTTFNLKAFAKEVVEEMQGYLKAGQQIAYQHEGEERTVNIDK
QLLKNILLNLLSNGSKYSAEGKTIRFTTSIANGAALVAVQDQGIGIPKADQAHLFTPFFR
AQNVTNIQGTGLGLNIVKKYVEVMDGKLEYQSELGEGTTFTITIPNTAEA