Protein Info for CA264_13320 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: 3-phosphoglycerate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 630 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 7 to 180 (174 residues), 55.8 bits, see alignment E=2.8e-19 PF12710: HAD" amino acids 8 to 180 (173 residues), 36.7 bits, see alignment E=1.2e-12 PF00389: 2-Hacid_dh" amino acids 235 to 547 (313 residues), 116.1 bits, see alignment E=1.9e-37 PF02826: 2-Hacid_dh_C" amino acids 340 to 515 (176 residues), 176.1 bits, see alignment E=9.3e-56 PF03446: NAD_binding_2" amino acids 374 to 479 (106 residues), 21.6 bits, see alignment E=3.8e-08

Best Hits

KEGG orthology group: K00058, D-3-phosphoglycerate dehydrogenase [EC: 1.1.1.95] (inferred from 66% identity to gfo:GFO_0734)

Predicted SEED Role

"D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 1.1.1.95)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.95

Use Curated BLAST to search for 1.1.1.95

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YTX4 at UniProt or InterPro

Protein Sequence (630 amino acids)

>CA264_13320 3-phosphoglycerate dehydrogenase (Pontibacter actiniarum KMM 6156, DSM 19842)
MSKDKYFIIDFDSTFTQVEALDELGAISLQNHPERERILEQVKQITDSAMAGSSSFAEGL
AKRLELLQAHQSHLPLLINRLKERVSESIRRNRDFLQEYADQILIVSSGFKEFITPIVTE
YGIKEENIYANTFHVDAQGNLTGFDKENLLSLDKGKIKLLEQLALPGDVYVLGDGYTDYE
IKEAGMANKFYAFTENVVRDSVVAKAEHIAPSLDEFLYQNKLPMAISYPKNRISVLLLEN
VHPQAVELFRREGYQVETVSGALSEEELCERIKNVSILGIRSKTHVTRKVLEHANRLMCV
GAFCIGTNQIDLDACLEAGITVLNAPYSNTRSVVELALGEIIILSRNVLDKSSKMHQGKW
DKSASGSFEVRDKKLGIVGYGNIGAQLSVLAEAMGMEVYYYDVVEKLQLGNARKCNTLHE
LLEKADYVTLHVDGRPENKHMFGAEEFATMKEGAIFLNLSRGHVVDLQALVASLKSGKIS
GAGIDVFPEEPATNSDPFESELRDLPNVILTPHIGGSTSEAQVNIANFVPNRIMDYINSG
NTYGSVNFPNLQLPELKNAHRLIHIHANVPGVLANINQVLAKNHVNILGQYLKTNERVGY
VITDIDKAYDKQVVNDMKQVPHTIKFRILY