Protein Info for CA264_13110 in Pontibacter actiniarum KMM 6156, DSM 19842
Annotation: 3-deoxy-7-phosphoheptulonate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K04516, chorismate mutase [EC: 5.4.99.5] (inferred from 57% identity to lby:Lbys_0765)Predicted SEED Role
"2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) / Chorismate mutase I (EC 5.4.99.5)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate (EC 2.5.1.54, EC 5.4.99.5)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (17/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- superpathway of L-phenylalanine biosynthesis (10/10 steps found)
- chorismate biosynthesis I (7/7 steps found)
- superpathway of L-tyrosine biosynthesis (9/10 steps found)
- L-phenylalanine biosynthesis I (3/3 steps found)
- 3-dehydroquinate biosynthesis I (2/2 steps found)
- L-phenylalanine biosynthesis II (3/4 steps found)
- L-tyrosine biosynthesis II (3/4 steps found)
- L-tyrosine biosynthesis III (3/4 steps found)
- L-tyrosine biosynthesis I (2/3 steps found)
- superpathway of L-phenylalanine and L-tyrosine biosynthesis (3/5 steps found)
- superpathway of chorismate metabolism (39/59 steps found)
- bacilysin biosynthesis (1/10 steps found)
- salinosporamide A biosynthesis (4/15 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.5.1.54, 5.4.99.5
Use Curated BLAST to search for 2.5.1.54 or 5.4.99.5
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9YTW7 at UniProt or InterPro
Protein Sequence (365 amino acids)
>CA264_13110 3-deoxy-7-phosphoheptulonate synthase (Pontibacter actiniarum KMM 6156, DSM 19842) MQLMKFNNPHSFFTALQAGQGHPLVIAGPCSAETEAQVMQTAEALKQQGVHLFRAGIWKP RTRPGSFEGVGSQGLAWLNRVKRELGLKVTTEVATARHVEEALKQEIDVLWIGARTTVNP FAVQEIADALQGVQVPVMVKNPVNPDLALWIGAIERFYHAGITDLAAIHRGFSSYQQTKY RNVPLWQIPIELKARYQGLPVIVDPSHIGGRRDLVFPVSQKGLDLGYDGVMIETHPTPEQ ALSDAAQQVTPARLAEIIGQLQVRKSTYDDAELVNRAEELRLQIDAADHEIIAALARRMA LVEQIGEYKKQNNVQVLQLERWKEIFRSRPEWAEEAGVNPAFVEELYKLIHVESIRKQTK VLDGI