Protein Info for CA264_13085 in Pontibacter actiniarum KMM 6156, DSM 19842
Annotation: methylmalonyl-CoA carboxyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 64% identical to PCCB_RHOS4: Propionyl-CoA carboxylase beta chain (pccB) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
KEGG orthology group: K01966, propionyl-CoA carboxylase beta chain [EC: 6.4.1.3] (inferred from 84% identity to mtt:Ftrac_3157)MetaCyc: 64% identical to propionyl-CoA carboxylase beta subunit (Cereibacter sphaeroides)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]
Predicted SEED Role
"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2); Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2, EC 6.4.1.3)
MetaCyc Pathways
- propanoyl CoA degradation I (3/3 steps found)
- 2-oxobutanoate degradation I (3/4 steps found)
- fatty acid biosynthesis initiation (type I) (1/3 steps found)
- anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
- superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
- 3-hydroxypropanoate cycle (8/13 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
- superpathway of L-methionine salvage and degradation (9/16 steps found)
- methylaspartate cycle (11/19 steps found)
- jadomycin biosynthesis (3/9 steps found)
- superpathway of the 3-hydroxypropanoate cycle (8/18 steps found)
- mycolate biosynthesis (23/205 steps found)
- superpathway of mycolate biosynthesis (24/239 steps found)
KEGG Metabolic Maps
- Fatty acid biosynthesis
- Propanoate metabolism
- Pyruvate metabolism
- Tetracycline biosynthesis
- Valine, leucine and isoleucine degradation
Isozymes
Compare fitness of predicted isozymes for: 6.4.1.2
Use Curated BLAST to search for 6.4.1.2 or 6.4.1.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9YTV3 at UniProt or InterPro
Protein Sequence (519 amino acids)
>CA264_13085 methylmalonyl-CoA carboxyltransferase (Pontibacter actiniarum KMM 6156, DSM 19842) MAGEIREAQIETLERKNAEALLGGGQDRIEAQHKKGKLTARERIHLLMDEGSFEEIGKFV MHRSKDFGLDKQYFLGDGVVTGYGTINGRLVYVFSQDFTVLGGSLSETHAEKIVKIMELA MKNGAPVIGLNDSGGARIQEGVVSLGGYADIFYRNTLASGVIPQISAIMGPCAGGAVYSP AITDFIMMVQDTSYMFVTGPNVVKTVTHENVTSEELGGASTHSTKSGVTHFSCANEVECI NYIKTLLSYIPQNCEELPPSLPYEPQADETREVLDTIVPENPNQPYDIREVIEGIIDADS FFEVHKNFGENIVVGFARLGGRSIGIVGNQPAVLAGVLDINASTKAARFVRFCDSFNVPL LVLEDVPGFLPGTDQEWRGIITNGAKLLYAFCEATVPRITVITRKAYGGAYDVMNSKHIG ADMNFAWPTAEIAVMGAQGAAEIIFKREIAAAEDPEAKLAEKVQEYKEKFATPYRAAHRG FIDEVIMPSETRAKLIKAFKMLENKAVTLPRKKHGNIPL