Protein Info for CA264_12870 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: deoxynucleoside kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 36% identical to DCK_BACSU: Deoxyadenosine/deoxycytidine kinase (dck) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 64% identity to fjo:Fjoh_1482)

MetaCyc: 36% identical to deoxyadenosine/deoxycytidine kinase monomer (Bacillus subtilis subtilis 168)
Deoxynucleoside kinase. [EC: 2.7.1.145, 2.7.1.74, 2.7.1.76]; 2.7.1.74 [EC: 2.7.1.145, 2.7.1.74, 2.7.1.76]

Predicted SEED Role

"Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)" in subsystem Purine conversions or PnuC-like transporters (EC 2.7.1.113, EC 2.7.1.76)

MetaCyc Pathways

superpathway of pyrimidine deoxyribonucleoside salvage (9/9 steps found)
purine deoxyribonucleosides salvage (6/6 steps found)
pyrimidine deoxyribonucleosides salvage (5/5 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.113 or 2.7.1.145 or 2.7.1.74 or 2.7.1.76

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YTM2 at UniProt or InterPro

Protein Sequence (204 amino acids)

>CA264_12870 deoxynucleoside kinase (Pontibacter actiniarum KMM 6156, DSM 19842)
MHIAIVGNIGAGKTTLATKLAQHFKWDLYLEAVDNNPYLKDFYEDMERWAFHLQVFFLNS
RFNQVQQIQANGHDVIQDRTIYEDAHIFARNLHQSGLMSTRDFDNYYGLFQSMISMVKAP
DLMIYLKADLPKLIGQIEKRNRDYESSISINYLRNLNEHYNTWMGNYDLGKLLVVDVNNI
DFVANPEDLGSIIEKIQGELFGLF