Protein Info for CA264_12600 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: 5-(carboxyamino)imidazole ribonucleotide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01161: phosphoribosylaminoimidazole carboxylase, ATPase subunit
  • amino acids 7 to 364 (358 residues), 387.3 bits, E=4e-120
• PF02222: ATP-grasp
  • amino acids 112 to 276 (165 residues), 149.8 bits, E=8.7e-48
• PF17769: PurK_C
  • amino acids 303 to 364 (62 residues), 74.3 bits, E=7.3e-25
• PF21244: PurT_C
  • amino acids 317 to 369 (53 residues), 31.9 bits, 1.1e-11

Best Hits

KEGG orthology group: K01589, 5-(carboxyamino)imidazole ribonucleotide synthase [EC: 6.3.4.18] (inferred from 59% identity to chu:CHU_3733)

Predicted SEED Role

"Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)" in subsystem De Novo Purine Biosynthesis (EC 4.1.1.21)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.21

Use Curated BLAST to search for 4.1.1.21 or 6.3.4.18

Sequence Analysis Tools

See A0A1X9YTG6 at UniProt or InterPro

Protein Sequence (376 amino acids)

>CA264_12600 5-(carboxyamino)imidazole ribonucleotide synthase (Pontibacter actiniarum KMM 6156, DSM 19842)
MKGEVKLGILGGGQLGRMLMQAGLDFNLYTLVLDPDENAPCKDICNEFYVGSFRDFDTVY
EFGKNCDILTIEIEHVNADALEKLEQEGVKVYPDANTVRTIQDKGLQKEFYKKHSIPTSD
FVLLKEKGELQQHTDFLPAFQKLRREGYDGRGVTRLTGEADFGKAFEEPSVLEKLVDFEK
EISVIVARNARGEVTAFPVVELSFHPEHNLVDSLFAPANVPYKLQRLAIEIATRVIESFG
MVGILAVEMFLTKDGQILVNEVAPRPHNSGHHTIKANYTSQYEQHLRAILNLPLGATDIQ
SAAVMLNLLGEPGYDGEAAYEGLQEALAVPGVYIHLYGKKYTRPARKMGHITVLGENIEE
AQQRAEQIRNVIKVKA