Protein Info for CA264_11125 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: bifunctional alpha,alpha-trehalose-phosphate synthase (UDP-forming)/trehalose-phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 738 TIGR02400: alpha,alpha-trehalose-phosphate synthase (UDP-forming)" amino acids 3 to 459 (457 residues), 578.2 bits, see alignment E=1.7e-177 PF00982: Glyco_transf_20" amino acids 3 to 460 (458 residues), 525.3 bits, see alignment E=1.5e-161 TIGR00685: trehalose-phosphatase" amino acids 491 to 723 (233 residues), 110 bits, see alignment E=2.7e-35 TIGR01484: HAD hydrolase, family IIB" amino acids 493 to 690 (198 residues), 67.9 bits, see alignment E=2.1e-22 PF02358: Trehalose_PPase" amino acids 495 to 698 (204 residues), 152.5 bits, see alignment E=1.1e-48

Best Hits

Swiss-Prot: 42% identical to TPSP_THETK: Bifunctional trehalose-6-phosphate synthase/phosphatase (tpsp) from Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)

KEGG orthology group: K00697, alpha,alpha-trehalose-phosphate synthase (UDP-forming) [EC: 2.4.1.15] (inferred from 53% identity to mtt:Ftrac_2520)

Predicted SEED Role

"Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC 2.4.1.15) / Trehalose-6-phosphate phosphatase (EC 3.1.3.12)" in subsystem Trehalose Biosynthesis (EC 2.4.1.15, EC 3.1.3.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.1.15 or 3.1.3.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YYD5 at UniProt or InterPro

Protein Sequence (738 amino acids)

>CA264_11125 bifunctional alpha,alpha-trehalose-phosphate synthase (UDP-forming)/trehalose-phosphatase (Pontibacter actiniarum KMM 6156, DSM 19842)
MAKLIIVSNRLPVKLQEKDEELSYKPSEGGLATGLGSIYKEGDNLWIGWPGLVVTEDKKQ
EQITTDLNQENMHPVFLTETEIKEFYEGFSNETLWPTFHYFSQYAVYDQQLWETYVAVNQ
KYCDAVVAQAGPEDTIWVHDYQLLLLPSMLREKLPDSTIGFFQHIPFPSYEVFRLLPWRK
ELLEGMLGSDLVGFHTYDDMRHFLSSVNRLVGYGSMHGWIHTPSRSLLVDSFPMGIDYEK
YSGTAALEEVKKRERIYRSNLNAEKIILSIDRLDYSKGIAQRLEAFELFLERYPEFHRKV
TLLMLVVPSRDAVEKYKELKEEVDEMVGRINGKYSHISWNPIQYFYRSYPLETLSAFYRM
ADVGLVTPMRDGMNLVCKEFVASKLDQKGVLILSEMAGASKELSDAILINPNDINQMVDS
IYHALVMPEEEQMQHMRNMQESLQRYNIHHWVSMFMDRLSYVKIKQLSLATSYLDESTFL
EMSDAYESASSRLFFLEYDGGLVDYRNRPLMARPDDELMALLERLSSSPKNRVVVMSSRE
KATMQDWLGHLNIDIIAEHGVWIKQRGTGWQTMLSLMDDWKKDIRLILDLYVDRTPGSFI
EEKEYSLVWHYRRVETGLGDLRARELVSHLNFLASNSNLQVLDGQMAVEVKAQEINKGKA
SSYWLSKFPHKFVMAVGDDWGDEDIFKAMPREAYTVKVGNASSVAKYHVDTCQEARDMLD
RLVQANTQEQSPGALMTG