Protein Info for CA264_09280 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: phosphoribosylaminoimidazolesuccinocarboxamide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 74% identical to PUR7_CYTH3: Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K01923, phosphoribosylaminoimidazole-succinocarboxamide synthase [EC: 6.3.2.6] (inferred from 74% identity to chu:CHU_1912)

Predicted SEED Role

"Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)" in subsystem De Novo Purine Biosynthesis (EC 6.3.2.6)

MetaCyc Pathways

superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
inosine-5'-phosphate biosynthesis I (6/6 steps found)
inosine-5'-phosphate biosynthesis II (5/5 steps found)
inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YRW6 at UniProt or InterPro

Protein Sequence (315 amino acids)

>CA264_09280 phosphoribosylaminoimidazolesuccinocarboxamide synthase (Pontibacter actiniarum KMM 6156, DSM 19842)
MEAIKETNFTFAGQTGFYKGKVRDVYYFEDRIAVVATDRISAFDVVLPRAIPYKGQVLNQ
MASLNLSATSDIVPNWVLSTPDPNVTIGYRCEPFKVEMVIRGYLAGHAWREYSAGKRTLC
GVALPEGLRENDKLPEPIITPTTKADEGHDEDISREEILAKGLVSEQDYLNLERYTRALF
ARGTDLAKERGLILVDTKYEFGKYNGQIFLIDEIHTPDSSRYFYSEGYAERQQSGEPQRQ
LSKEFVRKWLIEHGFQGKEGQQVPEMTDEVVNGISERYIELYEVFTGHKFEQEDYKNVLQ
RIEQHTSDNIFTAKS