Protein Info for CA264_08035 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: aspartate aminotransferase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00713: glutamate-1-semialdehyde-2,1-aminomutase
  • amino acids 7 to 427 (421 residues), 610.4 bits, E=7e-188
• PF00202: Aminotran_3
  • amino acids 36 to 417 (382 residues), 257.3 bits, E=1.1e-80

Best Hits

Swiss-Prot: 69% identical to GSA_CYTH3: Glutamate-1-semialdehyde 2,1-aminomutase (hemL) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K01845, glutamate-1-semialdehyde 2,1-aminomutase [EC: 5.4.3.8] (inferred from 72% identity to dfe:Dfer_1148)

MetaCyc: 55% identical to glutamate-1-semialdehyde 2,1-aminomutase subunit (Salmonella enterica enterica serovar Typhimurium)
Glutamate-1-semialdehyde 2,1-aminomutase. [EC: 5.4.3.8]

Predicted SEED Role

"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (10/10 steps found)
• tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)
• adenosylcobalamin biosynthesis II (aerobic) (13/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (13/36 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.3.8

Sequence Analysis Tools

See A0A1X9YRA4 at UniProt or InterPro

Protein Sequence (432 amino acids)

>CA264_08035 aspartate aminotransferase family protein (Pontibacter actiniarum KMM 6156, DSM 19842)
MIQAPVSNELFLRAQSSIPGGVNSPVRAFRAVGGNPRFMVSAKGPYMFDEDGNRYIDLIN
SWGPMILGHAADVVNEAVKEAIPNSLSFGAPTRKEIEIAELIVSMVPSIEKVRMVNSGTE
ATMSAIRVARGFTGRDKIIKFEGCYHGHGDSFLISAGSGAITLGVPDSPGVTKGTANDTL
TAPFNNLDAVRTLVEANKGQVAAIILEPVAGNMGLVTPAHGFLQGLRDLCDQEGIILIFD
EVMTGFRLSAGGAQQLYGVTPDMSTMGKIIGGGMPVGAYGGKKEIMDFVAPAGPVYQAGT
LSGNPIAMSAGMAMLTYLKEHPEVYTQLEQTTASMVAGMQQNMQKLGLNFTINRVGSMFS
IFFTEQPVTDFESAKTSDTAFFGRYFNAMLQRGVYLAPSQYEALFVSTAISEELVAQYVQ
ANYEALQEALQA