Protein Info for CA264_07760 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: acetyl-CoA carboxylase biotin carboxylase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00514: acetyl-CoA carboxylase, biotin carboxylase subunit
  • amino acids 1 to 442 (442 residues), 739.9 bits, E=5.2e-227
• PF00289: Biotin_carb_N
  • amino acids 1 to 110 (110 residues), 163.3 bits, E=7.5e-52
• PF02655: ATP-grasp_3
  • amino acids 114 to 294 (181 residues), 25.4 bits, E=4.3e-09
• PF02786: CPSase_L_D2
  • amino acids 115 to 321 (207 residues), 256.1 bits, E=6.9e-80
• PF02222: ATP-grasp
  • amino acids 138 to 292 (155 residues), 34.1 bits, E=6.2e-12
• PF07478: Dala_Dala_lig_C
  • amino acids 145 to 291 (147 residues), 36.9 bits, E=8.6e-13
• PF02785: Biotin_carb_C
  • amino acids 334 to 440 (107 residues), 149.7 bits, E=9.2e-48

Best Hits

Swiss-Prot: 60% identical to ACCC_ARATH: Biotin carboxylase, chloroplastic (CAC2) from Arabidopsis thaliana

KEGG orthology group: K01961, acetyl-CoA carboxylase, biotin carboxylase subunit [EC: 6.3.4.14 6.4.1.2] (inferred from 80% identity to dfe:Dfer_4148)

MetaCyc: 60% identical to biotin carboxylase (Arabidopsis thaliana col)
Biotin carboxylase. [EC: 6.3.4.14]

Predicted SEED Role

"Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.3.4.14)

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (4/4 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• 3-hydroxypropanoate cycle (8/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
• jadomycin biosynthesis (3/9 steps found)
• glyoxylate assimilation (5/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (8/18 steps found)
• superpathway of mycolate biosynthesis (24/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14, 6.4.1.2

Use Curated BLAST to search for 6.3.4.14 or 6.4.1.2

Sequence Analysis Tools

See A0A1X9YR48 at UniProt or InterPro

Protein Sequence (448 amino acids)

>CA264_07760 acetyl-CoA carboxylase biotin carboxylase subunit (Pontibacter actiniarum KMM 6156, DSM 19842)
MFKKILIANRGEIALRIIRTCKEMGIKTVAVYSTADKESLHVRFADEAVCIGPAPSAQSY
LNIPNIIAAAEITNADAIHPGYGFLSENAEFSRICAENGIKFIGASPEMINQMGDKASAK
DTMKKAGVPTIPGSDGLLKSVEEGLKIASKIQYPVILKATAGGGGRGMRIVKDASEFEKA
WNDARTESKAAFGNDGLYLEKFVVEPRHIEIQLIGDQHGQVAHLSERDCSIQRRHQKLVE
ETPSPFITDELREKMGQAAIAGAKAINYEGVGTIEFLVDKNRDFYFMEMNTRIQVEHPIT
EEVIDYDLIKEQIKVAAGHKITGKNYYPKMHAIECRINAEDPKNNFRPSPGKITTLHTPG
GHGVRVDSHVYSGYIIPPNYDSMIAKLIVSAQTREEALVKMKRALSEFVIEGIKTTVPFH
LKLMDDPGFKEGNFTTKYLEDFDFGAIE