Protein Info for CA264_07560 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: DNA helicase RecQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 710 TIGR01389: ATP-dependent DNA helicase RecQ" amino acids 8 to 594 (587 residues), 770.7 bits, see alignment E=9.6e-236 TIGR00614: ATP-dependent DNA helicase, RecQ family" amino acids 10 to 457 (448 residues), 579.8 bits, see alignment E=4.3e-178 PF00270: DEAD" amino acids 21 to 180 (160 residues), 90.5 bits, see alignment E=3.2e-29 PF00271: Helicase_C" amino acids 217 to 325 (109 residues), 79 bits, see alignment E=9.5e-26 PF16124: RecQ_Zn_bind" amino acids 336 to 398 (63 residues), 65.7 bits, see alignment E=1.6e-21 PF09382: RQC" amino acids 400 to 509 (110 residues), 97.7 bits, see alignment E=1.2e-31 PF00570: HRDC" amino acids 529 to 594 (66 residues), 79.7 bits, see alignment E=3.7e-26 PF14493: HTH_40" amino acids 612 to 699 (88 residues), 87.2 bits, see alignment E=2.2e-28

Best Hits

KEGG orthology group: K03654, ATP-dependent DNA helicase RecQ [EC: 3.6.4.12] (inferred from 56% identity to hhy:Halhy_6043)

Predicted SEED Role

"ATP-dependent DNA helicase RecQ" in subsystem DNA-replication or DNA repair, bacterial RecFOR pathway

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YQZ5 at UniProt or InterPro

Protein Sequence (710 amino acids)

>CA264_07560 DNA helicase RecQ (Pontibacter actiniarum KMM 6156, DSM 19842)
MATIREAREALKLYFGYEQFRPMQEQIIEGVLQGQDVVVLMPTGGGKSVCYQVPAVVQPG
MCVVVSPLIALMKDQVEALLANGIPAAYINSSQSAEQQYQIENQCLDGKLKLLYVSPEKL
LSSGFMAFLRRINISLFAVDEAHCISSWGHDFRPEYTQLKALKQQFPTTPVIALTATADK
LTQKDIQEQLYLRNPQVFVASFDRPNINLMVKPGKDRFNKITDFLMRRQKQPGIIYCLSR
KATESLADKLKRNGFNASYYHAGMSPNQRAKAQEDFLNDDTQIVCATIAFGMGIDKSNVR
WVIHYNLPKNVEGYYQEIGRAGRDGAQSDALLFYSYADVMNLRNMLQDNQNEAQTELQLV
KLERMQQFAEAAACRRRILLQYFGETMQKNCGNCDICRNPPTRFDGTVIAQKALSAIART
QERANMSLLVDVLRGARNAQVLQAGFDKVKTYGAGRDVSPLDWNRYLHQMLNEGLIEMAY
DQGYTLKLTEQSKEVLFSDRKVQLVKFEEVKQEEAAVKARPKRELIKDALFEKLRALRKS
LADEYGVPPYVIFTDTTLQEMAAERPTNKIAMLAISGVGAQKFERYGDAFITEIIDFINE
EQNKGTKMKGATHLATFELLKKGLSIEDVAQLRNLNPVTIFSHLATLYEQGYAVDVQRYV
SKAEYKVISKAIAKLGADAKLKDLFEALEEQYEYYKIRLSVSIFKKENTW