Protein Info for CA264_07375 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: NADH-dependent alcohol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 55% identical to YQHD_ECOLI: Alcohol dehydrogenase YqhD (yqhD) from Escherichia coli (strain K12)

KEGG orthology group: K08325, NADP-dependent alcohol dehydrogenase [EC: 1.1.-.-] (inferred from 66% identity to gvi:glr3827)

MetaCyc: 55% identical to NADPH-dependent aldehyde reductase YqhD (Escherichia coli K-12 substr. MG1655)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]

Predicted SEED Role

"NADH-dependent butanol dehydrogenase A (EC 1.1.1.-)" in subsystem Butanol Biosynthesis (EC 1.1.1.-)

MetaCyc Pathways

pyruvate fermentation to butanol II (engineered) (5/6 steps found)
1-butanol autotrophic biosynthesis (engineered) (19/27 steps found)
methylglyoxal degradation III (1/2 steps found)
1,3-propanediol biosynthesis (engineered) (6/9 steps found)
glycerol degradation to butanol (11/16 steps found)
pyruvate fermentation to butanol I (5/8 steps found)
superpathway of methylglyoxal degradation (4/8 steps found)
D-xylose degradation to ethylene glycol (engineered) (1/4 steps found)
L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
detoxification of reactive carbonyls in chloroplasts (4/10 steps found)
superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
traumatin and (Z)-3-hexen-1-yl acetate biosynthesis (3/12 steps found)
superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (6/17 steps found)
superpathway of lipoxygenase (4/22 steps found)
superpathway of pentose and pentitol degradation (7/42 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.-

Use Curated BLAST to search for 1.1.-.- or 1.1.1.- or 1.1.1.2 or 1.1.1.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YR01 at UniProt or InterPro

Protein Sequence (385 amino acids)

>CA264_07375 NADH-dependent alcohol dehydrogenase (Pontibacter actiniarum KMM 6156, DSM 19842)
MNNFTFYNPVKILFGKGQISAIAKEIPQGARIMVTYGGGSIKRNGVYDQVMEALKDFYVL
EFSDIEPNPHYETLMQAVDIAKRQQIDFFLAVGGGSVIDGTKFIVAAMEFEGEDPWDMMT
KRTPVKKAVPFGTVLTLPATGSEMNSGSVVTRVSTKEKLAFGSPLTFPKFSVLDPEATFT
LPVRQICNGVVDAFTHVLEQYLTYPVNAPLQDRMAEAVLLTLKEEGPKAVQNPQDYDTMA
NFMWAATMALNGVIRPGVPTDWSTHYIAHELTALHGIDHARTLAIVLPSLLRYKSEQKKE
KLLQYGSRVWGVNSGTEDERLEATVEATIAFFESLGIQTKLSDYEVGEDTIDTIIERFEA
RGVKDLGERADIQIADVRQILTMSL