Protein Info for CA264_07155 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: methylmalonyl-CoA mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02310: B12-binding
  • amino acids 16 to 114 (99 residues), 46.2 bits, E=8e-16
• PF03308: MeaB
  • amino acids 170 to 399 (230 residues), 144.9 bits, E=5.1e-46
• PF02492: cobW
  • amino acids 199 to 365 (167 residues), 31.2 bits, E=3.3e-11
• PF01642: MM_CoA_mutase
  • amino acids 560 to 692 (133 residues), 70.5 bits, E=2.2e-23
  • amino acids 759 to 1121 (363 residues), 313.7 bits, E=4.3e-97

Predicted SEED Role

"B12 binding domain / kinase domain / Methylmalonyl-CoA mutase (EC 5.4.99.2)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 5.4.99.2)

MetaCyc Pathways

• propanoyl CoA degradation I (3/3 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• pyruvate fermentation to propanoate I (4/7 steps found)
• conversion of succinate to propanoate (1/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
• 3-hydroxypropanoate cycle (8/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• methylaspartate cycle (11/19 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (6/13 steps found)
• L-glutamate degradation VIII (to propanoate) (4/11 steps found)
• superpathway of the 3-hydroxypropanoate cycle (8/18 steps found)
• crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (3/14 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 5.4.99.2

Use Curated BLAST to search for 5.4.99.2

Sequence Analysis Tools

See A0A1X9YQT1 at UniProt or InterPro

Protein Sequence (1128 amino acids)

>CA264_07155 methylmalonyl-CoA mutase (Pontibacter actiniarum KMM 6156, DSM 19842)
MQATTVEPYKPVNHIRIVTAASLFDGHDAAINIMRRIIQASGAEVIHLGHNRSVQEIVDC
AIQEDAQAIAITSYQGGHIEYFKYMYDLLNERGSGHIRIFGGGGGVILPVEIEELHEYGI
ARIYSPDDGRAMGLQGMINDMLQKCDFPTGQNLNGEYKHLQEKNPKDIARLISAAENFPE
EARGILNQVKDQAKEIKTPVLGITGTGGAGKSSLVDELVRRFLMDFPEKKIAIISVDPSK
RKTGGALLGDRIRMNSISNERVYMRSLATRQSNLALSKYVQDAVDIVKAASFDLIILETS
GIGQSDTEIIEHSDMSLYVMTPEYGAATQLEKIDMLDFADVIALNKFDKRGALDALRDVK
KQYKRNHQLWDVKDEDIPVFGTIASQFNDPGMNQLYRTIMGTISEKTGIAFDSNLQTSKE
MSEKVFIIPPSRTRYLSEISETIRSYDKWSNDQAEVAQKLYGIKKSIEAIQEIEVEDKDR
LVKQLEAAYAEVELNLDGQNKKILDNWKEKVQAYKNEFYVFKVRDKELKIKTHTESLSHL
QIPKVATPKYEAWGDLLKWNLQENVPGEFPYTAGVFPFKREGEDPTRMFAGEGGPERTNR
RFHYVSLGMPAKRLSTAFDSVTLYGEDPDYRPDIYGKIGNSGVSICCLDDAKKLYSGFNL
ADPKTSVSMTINGPAAILTGFFMNAAIDQQCELYIKEHGLEEEVEKKIEAIYKEKGAERP
SYQGKLPEGNDGLGLMLLGVTGDQVLPSEVYEPIKTRTLAAVRGTVQADILKEDQAQNTC
IFSTEFSLRLMGDVQQYFIDKNVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTFVEY
YVSRGMDINKFAPNLSFFFSNGIDPEYAVIGRVARRIWAKAMKHKYGADARSQMLKYHIQ
TSGRSLHAQEIDFNDIRTTLQALYAIYDNCNSLHTNAYDEAITTPTEASVRRAMAIQLII
NRELGLAKNENPLQGSFIIEELTDLVEEAVLTEFDRITERGGVLGAMETMYQRGKIQEES
LYYETLKHTGEYPIIGVNTFLSSKGSPTVIPTEVIRATEEEKKYQISMVHALQERNADKS
AEMLKRIQQVAINNGNIFEEMMDTVKFCSLGQITNALFEVGGQYRRNM