Protein Info for CA264_06635 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: DNA methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 538 PF12161: HsdM_N" amino acids 18 to 143 (126 residues), 73.4 bits, see alignment E=4.6e-24 PF02384: N6_Mtase" amino acids 176 to 498 (323 residues), 306.5 bits, see alignment E=3.4e-95 PF05175: MTS" amino acids 209 to 304 (96 residues), 23.7 bits, see alignment E=4.9e-09

Best Hits

KEGG orthology group: K03427, type I restriction enzyme M protein [EC: 2.1.1.72] (inferred from 68% identity to zpr:ZPR_4675)

Predicted SEED Role

"Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72)" in subsystem Restriction-Modification System (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YQJ0 at UniProt or InterPro

Protein Sequence (538 amino acids)

>CA264_06635 DNA methyltransferase (Pontibacter actiniarum KMM 6156, DSM 19842)
MAKKNTPTSTPKADIDFENELWNAANELRGAVAENQYKDYVLSLLFLKHLSERYEVRKQE
LQLSFLDEKSDYYNIEAHEQSEVLEDELEYQVKNVYRLPKEATWTYLRENAEQDDIKVKV
DQAFVLIDELLSKRNPDYKGVLEPIFVKSQLSPTQVAGLINLFSKEKFSEVNNPESDIYG
RVYEYYIGKFAMAEGSGAGQFFTPGSVVRLLVEMLEPLKGRIMDLACGSGGMFVQSLKFL
QAHGGDKNDISIYGQERYEGTLRLCKMNLLLRNLSFDVKLGDSLLQDRFPDLKADYALMN
PPFNISNWHPELLPDNDPRLFGAKDTFTTPGNANYMWFQTLWHHLSERGTAGVVMANGAM
TTGSAGEKNVREHMIQQGMVDCIVQMPDKLFLTTGIPACIFILSKNRDGRDGEHRERKNE
ILFIDARKLGTMASRRLRVFEDADVARIADTYHTWRNLGGNYSDTEGFCKAATLAEVAAN
NYVLSPGRYVGSEAEEDDGVPFEEKMKLLTTELAAQFEESALLEKRIRENLEGIGFGF