Protein Info for CA264_05145 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1547 TIGR00229: PAS domain S-box protein" amino acids 272 to 399 (128 residues), 29.3 bits, see alignment E=4.1e-11 amino acids 654 to 779 (126 residues), 49.7 bits, see alignment E=1.9e-17 amino acids 781 to 906 (126 residues), 92.6 bits, see alignment E=1.1e-30 amino acids 907 to 1030 (124 residues), 71.7 bits, see alignment E=3e-24 PF08447: PAS_3" amino acids 299 to 389 (91 residues), 33.8 bits, see alignment 1.9e-11 amino acids 807 to 891 (85 residues), 63 bits, see alignment 1.4e-20 PF08448: PAS_4" amino acids 414 to 528 (115 residues), 41.4 bits, see alignment 8.2e-14 amino acids 545 to 647 (103 residues), 28.7 bits, see alignment 7.3e-10 amino acids 664 to 773 (110 residues), 52.6 bits, see alignment 2.7e-17 amino acids 791 to 900 (110 residues), 36.6 bits, see alignment 2.5e-12 PF00989: PAS" amino acids 659 to 764 (106 residues), 35.3 bits, see alignment 5.8e-12 amino acids 788 to 896 (109 residues), 41.5 bits, see alignment 6.7e-14 amino acids 912 to 969 (58 residues), 27.1 bits, see alignment (E = 2e-09) PF13426: PAS_9" amino acids 671 to 771 (101 residues), 32.2 bits, see alignment 5.9e-11 amino acids 796 to 898 (103 residues), 40.7 bits, see alignment 1.3e-13 amino acids 923 to 1022 (100 residues), 32 bits, see alignment 7e-11 PF14598: PAS_11" amino acids 798 to 899 (102 residues), 33 bits, see alignment 2.8e-11 PF00512: HisKA" amino acids 1044 to 1108 (65 residues), 73.4 bits, see alignment (E = 6.7e-24) PF02518: HATPase_c" amino acids 1155 to 1268 (114 residues), 97.5 bits, see alignment 3.7e-31 PF00072: Response_reg" amino acids 1294 to 1407 (114 residues), 88.3 bits, see alignment 2.2e-28 PF01627: Hpt" amino acids 1460 to 1534 (75 residues), 34.9 bits, see alignment 8.1e-12

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YPS3 at UniProt or InterPro

Protein Sequence (1547 amino acids)

>CA264_05145 hybrid sensor histidine kinase/response regulator (Pontibacter actiniarum KMM 6156, DSM 19842)
MAIVHTREELHDLLKTEREARLAAEKQAEAHLRELEALRKAKEAPAITYVQNWLLNNLKY
AAVVTDSAGNIMSINDEFVKLFLLPAPQEAYIGTPLEELEKQTLLSHLIPHREALANGNL
YDDATLPDGTVVERENMPLSDGSNHCGTAWFYRDVTTRRQRLRKMELQSELQEEYPNPVL
RLSFQGEILFGNIAGHDFLQEVAERRQALQRLLLLHINHLKIEEHSKPASFESYIAKRFY
YILIIPIPDKGYFNLYMTDVTERRKAEDALKDSQNFVRNIARTIPNIIYIYDLEENSCIY
LNEQVQNLLEFSQEEIEAFGRRVLSSLIMPEERYKLRQHALRMAQAKDGEIQEVEYLIRS
KSGQVKNLFCRESVFKRKENGQVKQIIGSAEDVTKVREQSMELRRQKEFYESILNHIPSD
VAVYNRDLQYLFLNPAAVADPELRQWIIGKTNEDYSRLRGVPPERMEHRGRHLRRVLEEK
KRIEFEEKLQTKNGDYTYHIRRLNPVLNKEGEVELVIAHGLTITDLRRAQEEIMASESKN
RAILAAIPDLMFIINEEGNYLDMKNVDQKHLLIPKNDVIGNNIYNILPEALASKIMGLLV
HVIKTGSYERINYDLELPEGLRHYEGRILKYSDNEVLGIIRDVTEEKKAAKEVEEKNEFI
RQVLNASPSLIYVKDGEGRFVLANQEFAKLFDMPLQDLIGSSGLDIHQQTNEAEFYLKVD
QQVIEENREIKLLERHTTKSGETLWFNTTKKPIVTSDGQTHVLGISTNVTEQRLANKRLQ
NSEELHRLLSENSKDMVSLHNLDGSYIYVSKAAEEMLGYTQAELLLMHPREIVHPDDLGQ
VHEQGYMEALEHCQNTTVQYRMLRRDGSVLWVETSIKPIQDAAQQVTKLQAATRDISDRR
KANEALKRSEKKYRDLINYSQAFICTHDLEGTIQSVNPYLLNMLGYEMEEMIGYNLIDFF
PKDDRASFYLYLKQFEEKSVVDGVLTILNKEHEERYLYYQNYKVEEPNMAPYIIAIAQDI
TDRMRTEQQLMKAKEAAEESARVKENFLANMSHEIRTPMNGILGMAGLLRKTELNEVQLN
YLNIIRQSADNLLVVINDILDIAKIEAGKLDLEEIPFSLTEAVQSAFQTFIYKAEEKEIG
YILEPVELEHTMVVGDPYRLNQVLLNLLNNAIKFTDEGSIRLSCQVLEESDAELTVQFTV
ADTGIGIPKSKMEYIFEGFTQAYSSTTRKYGGTGLGLNICKNLIEMQHGRIWVESEEDSG
SAFNFVLTYRKSKAAESEAYEEAIDFGSLGTIDVLLAEDNEVNIFLAQSILEGWGARVDV
AYNGREAVELAEQKLYDVVLMDIQMPELSGIDATHFIRCLADTAKASVPIIALTANALKG
DAEKYIAAGMNDYISKPFEEEKLFMKIAANLPQRRPQVSGTKFLQDKHIMQEIVNEPLYD
LAMLQKMSRGNEAFIKRTKQLFIETVPVTVADMQEKRDQADWTGVSAAAHKLKSTIDTMR
IEKLKDVVREIESGAKAQEDLEAVQQNIELLSHVMGQVVAQLQASLN